ArticleFrontiers in cellular and infection microbiology2023
Pre-epidemic evolution of the MRSA USA300 clade and a molecular key for classification.
Article in Frontiers in cellular and infection microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Whole-genome sequencing ofMicrobiology spectrum · 2026Article
- Conserved and context-dependent changes in pathogen and host cell gene expression during Staphylococcus aureus intracellular infection.BMC microbiology · 2026Article
- Empowering global disease surveillance with CURED: a tool for rapid identification of unique genomic biomarkers.mSystems · 2026Article
- Comparative Genomic and Epidemiologic Analysis of Methicillin-ResistantAntibiotics (Basel, Switzerland) · 2026Article
- StaphScope: a species-optimized computational pipeline for rapid and accessible Staphylococcus aureus genotyping and surveillance.BMC genomics · 2026Article
- Carbapenem-resistantMicrobiology spectrum · 2026Article
- Genome-wide association analysis provides insights into the genomics and extracellular expression ofVirulence · 2025Article
- Review
- Dynamic Networks of Methicillin-ResistantOpen forum infectious diseases · 2025Article
- What Do We Gain When Tolerating Loss? The Information Bottleneck Wrings Out Recombination.Molecular biology and evolution · 2025Article
- Review
- In Silico Exploration of Staphylococcal Cassette ChromosomeMicroorganisms · 2025Article
- Gradual loss of mobile genetic elements inISME communications · 2025Article
- Evolution of strain diversity and virulence factor repertoire in pediatric Staphylococcus aureus isolates.PloS one · 2025Article
- Genomics unveils country-to-country transmission between animal hospitals of a multidrug-resistant and sequence type 2Microbial genomics · 2024Article
- Pathogenomic profile and clonal diversity of potential zoonotic MRSA-CC7-ST789-t091-SCCmecV from human skin and soft tissue infections.Scientific reports · 2024Article
- Molecular and Phylogenomic Analysis of a Vancomycin Intermediate Resistance USA300LV Strain in Chile.Microorganisms · 2024Article
- Strain Differences in Bloodstream and Skin Infection: Methicillin-ResistantOpen forum infectious diseases · 2024Article
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7 authors.
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Abstract
Introduction: USA300 has remained the dominant community and healthcare associated methicillin-resistant Methods: Here, we take advantage of the accrued, publicly available data, as well as two newly sequenced pre-epidemic historical isolates from 1996, and a very early diverging ACME-negative NAE genome, to understand the pre-epidemic evolution of USA300. We use database mining techniques to emphasize genomes similar to pre-epidemic isolates, with the goal of reconstructing the early molecular evolution of the USA300 lineage. Results: Phylogenetic analysis with these genomes confirms that the NAE and SAE USA300 lineages diverged from a most recent common ancestor around 1970 with high confidence, and it also pinpoints the independent acquisition events of the of the ACME and COMER loci with greater precision than in previous studies. We provide evidence for a North American origin of the USA300 lineage and identify multiple introductions of USA300 into South and North America. Notably, we describe a third major USA300 clade (the pre-epidemic branching clade; PEB1) consisting of both MSSA and MRSA isolates circulating around the world that diverged from the USA300 lineage prior to the establishment of the South and North American epidemics. We present a detailed analysis of specific sequence characteristics of each of the major clades, and present diagnostic positions that can be used to classify new genomes.
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