ArticleFrontiers in psychiatry2023
The Static and dynamic functional connectivity characteristics of the left temporoparietal junction region in schizophrenia patients with auditory verbal hallucinations during low-frequency rTMS treatment.
Article in Frontiers in psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 4 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- The effectiveness of non-pharmacological treatments for auditory verbal hallucinations in schizophrenia spectrum disorders: A systematic review and meta-analysis.European psychiatry : the journal of the Association of European Psychiatrists · 2025Pooled it
- Accelerated neurostimulation protocols for auditory hallucinations: a systematic review and meta-analysis.Frontiers in psychiatry · 2025Pooled it
- Functional and structural effects of repetitive transcranial magnetic stimulation (rTMS) for the treatment of auditory verbal hallucinations in schizophrenia: A systematic review.Schizophrenia research · 2024Pooled it
- Transcranial Magnetic Stimulation and Transcranial Direct Current Stimulation Across Mental Disorders: A Systematic Review and Dose-Response Meta-Analysis.JAMA network open · 2024Pooled it
- Functional gradient analysis reveals potential therapeutic mechanisms of nrTMS for postoperative motor deficits in glioma patients: A randomized controlled trial.NeuroImage. Clinical · 2026Trial
- Targeting auditory verbal hallucinations in schizophrenia: effective connectivity changes induced by low-frequency rTMS.Translational psychiatry · 2024Trial
- Unravelling the genetic and molecular basis of low-frequency rTMS induced changes in functional connectivity density in schizophrenia patients with auditory verbal hallucinations.Translational psychiatry · 2025Article
- Low-frequency rTMS modulates small-world network properties in an AVH-related brain network in schizophrenia.Frontiers in psychiatry · 2025Article
- Advances in magnetic field approaches for non-invasive targeting neuromodulation.Frontiers in human neuroscience · 2025Review
- Alterations in sulcal depth and associated functional connectivity in schizophrenia with auditory verbal hallucinations.Frontiers in psychiatry · 2025Article
- Altered language-salience network connectivity in schizophrenia and differential associations with emotion regulation.Frontiers in psychiatry · 2025Article
- The alterations of repetitive transcranial magnetic stimulation on the energy landscape of resting-state networks differ across the human cortex.Human brain mapping · 2024Article
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7 authors.
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Abstract
Background: Auditory verbal hallucinations (AVH) are a core symptom of schizophrenia. Low-frequency (e.g., 1 Hz) repetitive transcranial magnetic stimulation (rTMS) targeting language processing regions (e.g., left TPJ) has been evident as a potential treatment for AVH. However, the underlying neural mechanisms of the rTMS treatment effect remain unclear. The present study aimed to investigate the effects of 1 Hz rTMS on functional connectivity (FC) of the temporoparietal junction area (TPJ) seed with the whole brain in schizophrenia patients with AVH. Methods: Using a single-blind placebo-controlled randomized clinical trial, 55 patients with AVH were randomly divided into active treatment group ( Results: Overall, symptom improvement following 1 Hz rTMS treatment was found in the active treatment group, whereas no change occurred in the placebo group. Moreover, decreased static FC (SFC) of the left TPJ with the right temporal lobes, as well as increased SFC with the prefrontal cortex and subcortical structure were observed in active rTMS group. Increased dynamic FC (DFC) of the left TPJ with frontoparietal areas was also found in the active rTMS group. However, seed-based SFC and DFC were reduced to a great extent in the placebo group. In addition, these changed FC (SFC) strengths in the active rTMS group were associated with reduced severity of clinical outcomes (e.g., positive symptoms). Conclusion: The application of 1 Hz rTMS over the left TPJ may affect connectivity characteristics of the targeted region and contribute to clinical improvement, which shed light on the therapeutic effect of rTMS on schizophrenia with AVH.
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