Evidence map›Paper›PMID 36761727›Full record

ArticleFrontiers in immunology2023

Silent neonatal influenza A virus infection primes systemic antimicrobial immunity.

Anna Sophie Heinemann, Jan Lennart Stalp, João Pedro Pereira Bonifacio, Filo Silva, Maike Willers, Julia Heckmann, Beate Fehlhaber, Lena Völlger, Dina Raafat, Nicole Normann and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Analysis of influenza A, influenza B andFrontiers in public health · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 3 countries.

Anna Sophie HeinemannDepartment of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany.
Jan Lennart StalpDepartment of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany.
João Pedro Pereira BonifacioDepartment of Microbiology and Molecular Medicine, University of Geneva, Geneva, Switzerland.
Filo SilvaDepartment of Microbiology and Molecular Medicine, University of Geneva, Geneva, Switzerland.
Maike WillersDepartment of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany.
Julia HeckmannDepartment of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany.
Beate FehlhaberDepartment of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany.
Lena VöllgerDepartment of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany.
Dina RaafatInstitute of Immunology, University Medicine Greifswald, Greifswald, Germany.
Nicole NormannInstitute of Immunology, University Medicine Greifswald, Greifswald, Germany.
Andreas KlosInstitute for Medical Microbiology and Hospital Epidemiology, Hannover Medical School, Hannover, Germany.
Gesine HansenDepartment of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany.
Mirco SchmolkeDepartment of Microbiology and Molecular Medicine, University of Geneva, Geneva, Switzerland.
Dorothee ViemannDepartment of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany.
Medizinische Hochschule Hannover · DEUniversity of Geneva · CHUniversitätsmedizin Greifswald · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Infections with influenza A viruses (IAV) cause seasonal epidemics and global pandemics. The majority of these infections remain asymptomatic, especially among children below five years of age. Importantly, this is a time, when immunological imprinting takes place. Whether early-life infections with IAV affect the development of antimicrobial immunity is unknown. Using a preclinical mouse model, we demonstrate here that silent neonatal influenza infections have a remote beneficial impact on the later control of systemic juvenile-onset and adult-onset infections with an unrelated pathogen,

Indexed as

Anti-Infective AgentsInfluenza A virusInfluenza, HumanInfluenza VaccinesAnimalsHumansMiceAnti-Infective AgentsInfluenza Vaccinesantimicrobial immunityinfluenza A virusinfluenza vaccinationinnate immunity trainingneonatesepsisStaphylococcus aureus

Identifiers

PMID36761727
PMCPMC9902881
OpenAlexW4317906857

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.