Evidence map›Paper›PMID 36761474›Full record

ReviewBeilstein journal of organic chemistry2023

1,4-Dithianes: attractive C2-building blocks for the synthesis of complex molecular architectures.

Bram Ryckaert, Ellen Demeyere, Frederick Degroote, Hilde Janssens, Johan M Winne

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Beilstein journal of organic chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Bram RyckaertDepartment of Organic and Macromolecular Chemistry, Ghent University, Krijgslaan 281 (S4), 9000 Gent, Belgium.ORCID https://orcid.org/0000-0002-5075-0307
Ellen DemeyereDepartment of Organic and Macromolecular Chemistry, Ghent University, Krijgslaan 281 (S4), 9000 Gent, Belgium.ORCID https://orcid.org/0000-0003-1016-3025
Frederick DegrooteDepartment of Organic and Macromolecular Chemistry, Ghent University, Krijgslaan 281 (S4), 9000 Gent, Belgium.ORCID https://orcid.org/0000-0002-2625-9358
Hilde JanssensDepartment of Organic and Macromolecular Chemistry, Ghent University, Krijgslaan 281 (S4), 9000 Gent, Belgium.ORCID https://orcid.org/0000-0001-6764-7181
Johan M WinneDepartment of Organic and Macromolecular Chemistry, Ghent University, Krijgslaan 281 (S4), 9000 Gent, Belgium.ORCID https://orcid.org/0000-0002-9015-4497

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This review covers the synthetic applications of 1,4-dithianes, as well as derivatives thereof at various oxidation states. The selected examples show how the specific heterocyclic reactivity can be harnessed for the controlled synthesis of carbon-carbon bonds. The reactivity is compared to and put into context with more common synthetic building blocks, such as 1,3-dithianes and (hetero)aromatic building blocks. 1,4-Dithianes have as yet not been investigated to the same extent as their well-known 1,3-dithiane counterparts, but they do offer attractive transformations that can find good use in the assembly of a wide array of complex molecular architectures, ranging from lipids and carbohydrates to various carbocyclic scaffolds. This versatility arises from the possibility to chemoselectively cleave or reduce the sulfur-heterocycle to reveal a versatile C2-synthon.

Indexed as

1,4-dithianes1,4-dithiins2,3-dihydro-1,4-dithiinsheterocyclestarget synthesis

Identifiers

PMID36761474
PMCPMC9907017

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.