Evidence map›Paper›PMID 36760639›Full record

ArticleFrontiers in plant science2023

Plant production of a virus-like particle-based vaccine candidate against porcine reproductive and respiratory syndrome.

Jordan T VanderBurgt, Ondre Harper, Christopher P Garnham, Susanne E Kohalmi, Rima Menassa

Open access · goldAbstract read
In one paragraph

Article in Frontiers in plant science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Jordan T VanderBurgtBiology Department, University of Western Ontario, London, ON, Canada.
Ondre HarperLondon Research and Development Centre, Agriculture and Agri-Food Canada, London, ON, Canada.
Christopher P GarnhamLondon Research and Development Centre, Agriculture and Agri-Food Canada, London, ON, Canada.
Susanne E KohalmiBiology Department, University of Western Ontario, London, ON, Canada.
Rima MenassaBiology Department, University of Western Ontario, London, ON, Canada.
London Research and Development CentreWestern University · CAAgriculture and Agri-Food Canada · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Porcine reproductive and respiratory syndrome (PRRS) is a disease leading to spontaneous abortions and stillbirths in sows and lowered life quality and expectancy in growing pigs. PRRS is prevalent worldwide and has significant economic impacts to swine industries around the globe. Co-expression of the two most abundant proteins in the viral envelope, the matrix protein (M) and glycosylated protein 5 (GP5), can produce a neutralizing immune response for the virus providing a potentially effective subunit vaccine against the disease, but these proteins are difficult to express. The goal of this research was to display antigenic portions of the M and GP5 proteins on the surface of tobacco mosaic virus-like particles. A modified tobacco mosaic virus coat protein (TMVc) was transiently expressed in

Indexed as

plant molecular farmingPRRS (porcine reproductive and respiratory syndrome virus)PRRSVsubunit vaccinetobacco mosaic virusvirus-like particle

Identifiers

PMID36760639
PMCPMC9902946
OpenAlexW4317885844

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.