Evidence map›Paper›PMID 36760564›Full record

ArticleFrontiers in cardiovascular medicine2023

Resting coronary flow drives the daily pattern in coronary flow reserve in patients with chest pain without obstructive epicardial stenosis.

Saurabh S Thosar, Sahar Taqui, Brian Davidson, Todd Belcik, James Hodovan, Sean P M Rice, Jonathan R Lindner

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cardiovascular medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Saurabh S ThosarOregon Institute of Occupational Health Sciences, Portland, OR, United States.
Sahar TaquiOHSU Knight Cardiovascular Institute, School of Medicine, Portland, OR, United States.
Brian DavidsonOHSU Knight Cardiovascular Institute, School of Medicine, Portland, OR, United States.
Todd BelcikOHSU Knight Cardiovascular Institute, School of Medicine, Portland, OR, United States.
James HodovanOHSU Knight Cardiovascular Institute, School of Medicine, Portland, OR, United States.
Sean P M RiceOregon Institute of Occupational Health Sciences, Portland, OR, United States.
Jonathan R LindnerDivision of Cardiovascular Medicine, Robert M. Berne Cardiovascular Research Center, Charlottesville, VA, United States.
Cardiovascular Institute of the South · USOregon Health & Science University · US

Funding

Upgrade of confocal microscopy at the Oregon National Primate Research CenterP51OD011092 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Bonnie J. Nagel · 2012 to 2026
$203.9M
Oregon Clinical and Translational Research Institute KL2 SupplementKL2TR002370 · NCATS · OREGON HEALTH & SCIENCE UNIVERSITY · PI Catherine Lee Hough · 2017 to 2026
$10.1M
Targeted CEU Imaging of Atherosclerosis and AngiogenesisR01HL078610 · NHLBI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI LINDNER, JONATHAN R · 2004 to 2022
$6.8M
Augmentation of Tissue Perfusion with Ultrasound-mediated CavitationR01HL130046 · NHLBI · UNIVERSITY OF VIRGINIA · PI LINDNER, JONATHAN R · 2016 to 2023
$5.5M
Sleep and circadian mechanisms in hypertensionR01HL163232 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI Saurabh Suhas Thosar · 2022 to 2026
$2.9M
NCATS NIH HHS KL2 TR002370NHLBI NIH HHS R01 HL078610NHLBI NIH HHS R01 HL130046NHLBI NIH HHS R01 HL163232NIH HHS P51 OD011092
6 · The paper itself

Abstract

Objectives: Ischemia with no obstructive coronary artery disease (INOCA) is a risk factor for major adverse cardiovascular events and is characterized by abnormal coronary microvascular tone. In patients with INOCA, adverse cardiovascular events most commonly occur in the morning compared to other times of the day and night. Materials and methods: We tested whether coronary microvascular function varies diurnally with attenuation in the morning in patients with symptomatic coronary artery disease without significant (>50%) epicardial stenosis. We evaluated data from 17 patients studied in the AM (700-1159 h) and 11 patients in the PM (1200-1800 h). Coronary microvascular function was measured using perfusion contrast imaging at rest and after infusion of intravenous regadenoson. We calculated microvascular flow reserve as the ratio of hyperemic to resting flow. Along with independent sample Results and conclusion: The AM and PM groups were matched for demographic and existing risk factors. Coronary microvascular flow reserve was ∼33% higher in the AM compared to the PM (

Indexed as

coronary flow reservediurnal variationischemia and non-obstructive coronary artery diseasemicrovascular dysfunctionmyocardial contrast echocardiographyperfusion imagingregadenoson stress

Identifiers

PMID36760564
PMCPMC9905716
OpenAlexW4318041791

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.