Evidence map›Paper›PMID 36760352›Full record

ArticleOxidative medicine and cellular longevity2023

circ_0001274 Competitively Binds miR-143-3p to Upregulate VWF Expression to Improve Acute Traumatic Coagulopathy.

Yong Luo, Shan Liu, Qing Li, Yonghu Zhang, Yong Fu, Ning Yang, Jian Zeng, Taifa Tan, Jun Hu, Fang Li and 7 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oxidative medicine and cellular longevity, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 2 institutions in 1 country.

Yong LuoHengyang Medical School, University of South China, Hengyang 421001, China.
Shan LiuTrauma Center, Hengyang Medical School, The Second Affiliated Hospital, University of South China, Hengyang 421001, Hunan Province, China.
Qing LiTrauma Center, Hengyang Medical School, The Second Affiliated Hospital, University of South China, Hengyang 421001, Hunan Province, China.
Yonghu ZhangTrauma Center, Hengyang Medical School, The Second Affiliated Hospital, University of South China, Hengyang 421001, Hunan Province, China.
Yong FuTrauma Center, Hengyang Medical School, The Second Affiliated Hospital, University of South China, Hengyang 421001, Hunan Province, China.
Ning YangTrauma Center, Hengyang Medical School, The Second Affiliated Hospital, University of South China, Hengyang 421001, Hunan Province, China.
Jian ZengTrauma Center, Hengyang Medical School, The Second Affiliated Hospital, University of South China, Hengyang 421001, Hunan Province, China.
Taifa TanTrauma Center, Hengyang Medical School, The Second Affiliated Hospital, University of South China, Hengyang 421001, Hunan Province, China.
Jun HuTrauma Center, Hengyang Medical School, The Second Affiliated Hospital, University of South China, Hengyang 421001, Hunan Province, China.
Fang LiTrauma Center, Hengyang Medical School, The Second Affiliated Hospital, University of South China, Hengyang 421001, Hunan Province, China.
Liang ZengTrauma Center, Hengyang Medical School, The Second Affiliated Hospital, University of South China, Hengyang 421001, Hunan Province, China.
Wenchao ZhangTrauma Center, Hengyang Medical School, The Second Affiliated Hospital, University of South China, Hengyang 421001, Hunan Province, China.
Zhanchen LiaoHengyang Medical School, University of South China, Hengyang 421001, China.
Kai WuDepartment of Rehabilitation Medicine, Xiangya Hospital, Central South University, Changsha 4140000, China.
Yu HuCenter for Experimental Medical Research, Third Xiangya Hospital, Central South University, Changsha 410013, China.
Zhigang LuoHengyang Medical School, University of South China, Hengyang 421001, China.ORCID https://orcid.org/0000-0002-0510-0946
Jian PengDepartment of General Surgery, Xiangya Hospital, Central South University, Changsha 410008, China.ORCID https://orcid.org/0000-0001-8051-3209
University of South China · CNCentral South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Accumulating evidence has noted the circRNA-microRNA- (circRNA-miRNA-) mRNA competing endogenous RNA (ceRNA) regulatory network in disease development and progression. The current study explored the ceRNA network in acute traumatic coagulopathy (ATC). Potential ATC-related genes were screened, and upstream miRNAs and circRNAs of VWF (the candidate target) were assayed through database searching and high-throughput sequencing technology. circ_0001274/miR-143-3p/VWF ceRNA regulatory network was constructed and validated. The expression of circ_0001274/miR-143-3p/VWF was determined in the peripheral blood samples from ATC patients and ATC mouse models. Online database and circRNA sequencing analysis results identified VWF as a key gene in ATC as supported by assays and that VWF was lowly expressed in ATC patients and mice. Further experiments demonstrated that miR-143-3p could target and inhibit VWF, and circ_0001274 could competitively sponge miR-143-3p. Functionally, circ_0001274 could competitively sequester miR-143-3p to upregulate VWF expression, potentially improving ATC. Our study highlights the critical role of circ_0001274/miR-143-3p/VWF axis in improving ATC.

Indexed as

Blood Coagulation DisordersMicroRNAsAnimalsBandagesMiceRNA, Circularvon Willebrand FactorMicroRNAsRNA, Circularvon Willebrand Factor

Identifiers

PMID36760352
PMCPMC9904904
OpenAlexW4318703260

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.