Evidence map›Paper›PMID 36760206›Full record

ReviewEuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology2023

Left atrial appendage occlusion.

David R Holmes, Kasper Korsholm, Josep Rodés-Cabau, Jacqueline Saw, Sergio Berti, Mohamad A Alkhouli

Registry-linked trialAbstract readReview
In one paragraph

Review in EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06177704 (Recurrent or Persistent Device Related Thrombus After Left Atrial Appendage Occlusion), which is not on this map. Cited by 58 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06177704 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Recurrent or Persistent Device Related Thrombus After Left Atrial Appendage Occlusion: The RE-DRT Study

TypeobservationalSponsorInstitut universitaire de cardiologie et de pneumologie de Québec, University LavalRan2026 to 2028Enrolled100ConditionsPercutaneous Left Atrial Appendage Occlusion (LAAO), Device-related Thrombus (DRT), Thromboembolic Event, Major Cardioembolic Events
3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Left atrial appendage occlusion in patients with end-stage renal disease: an individual patient-level meta-analysis.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025
    Pooled it
  2. Pooled it
  3. Review
  4. Review
  5. Review
  6. Article
  7. Effect of Left Atrial Appendage Closure on Cardiac Function.Journal of cardiovascular development and disease · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Percutaneous left atrial appendage closure for stroke prevention: current challenges and future perspectives.Clinical research in cardiology : official journal of the German Cardiac Society · 2026
    Review
  14. Left atrial appendage occlusion: trends in demographics and in-hospital outcomes-a German nationwide analysis.Clinical research in cardiology : official journal of the German Cardiac Society · 2026
    Observational
  15. Article
  16. Review
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

David R HolmesDepartment of Cardiology, Mayo Clinic School of Medicine, Rochester, MN, USA.
Kasper KorsholmDepartment of Cardiology, Aarhus University Hospital, Aarhus, Denmark.
Josep Rodés-CabauQuebec Heart and Lung Institute, Laval University, Quebec City, QC, Canada.
Jacqueline SawDivision of Interventional Cardiology, Vancouver General Hospital and the University of British Columbia, Vancouver, BC, Canada.
Sergio BertiCardiology Unit, Fondazione Toscana Gabriele Monasterio, Massa, Italy.
Mohamad A AlkhouliDepartment of Cardiology, Mayo Clinic School of Medicine, Rochester, MN, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prevention of stroke represents a goal of primary importance in health systems due to its associated morbidity and mortality. As several patient groups with increased stroke rates have been identified, multiple approaches have been developed and implemented: oral anticoagulation (OAC) for patients with atrial fibrillation, surgical and percutaneous revascularisation in patients with carotid disease, device closure for patients with patent foramen ovale, and now, left atrial appendage occlusion (LAAO) for selected patients with non-valvular atrial fibrillation (NVAF). The latter group of patients are the focus of this review which evaluates the pathophysiology, selection of patients, procedural performance, outcomes of treatment both during and post-procedure, adjunctive therapy, complications, and longer-term outcomes.

Indexed as

Atrial AppendageAtrial FibrillationForamen Ovale, PatentStrokeAnticoagulantsHumansTreatment OutcomeAnticoagulants

Identifiers

PMID36760206
PMCPMC9909459

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.