Evidence map›Paper›PMID 36760126›Full record

ArticleMolecular therapy : the journal of the American Society of Gene Therapy2023

Stable HIV decoy receptor expression after in vivo HSC transduction in mice and NHPs: Safety and efficacy in protection from SHIV.

Chang Li, Anna Kate Anderson, Hongjie Wang, Sucheol Gil, Jiho Kim, Lishan Huang, Audrey Germond, Audrey Baldessari, Veronica Nelson, Katharine J Bar and 4 more

Erratum issuedOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy : the journal of the American Society of Gene Therapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Durable antiviral protection via directMolecular therapy. Advances · 2026
    Article
  2. Molecular therapy. Advances · 2026
    Article
  3. Article
  4. Article
  5. Molecular therapy. Methods & clinical development · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Chang LiDepartment of Medicine, Division of Medical Genetics, University of Washington, Seattle, WA 98195, USA. Electronic address: cli1239@uw.edu.
Anna Kate AndersonDepartment of Medicine, Division of Medical Genetics, University of Washington, Seattle, WA 98195, USA.
Hongjie WangDepartment of Medicine, Division of Medical Genetics, University of Washington, Seattle, WA 98195, USA.
Sucheol GilDepartment of Medicine, Division of Medical Genetics, University of Washington, Seattle, WA 98195, USA.
Jiho KimDepartment of Medicine, Division of Medical Genetics, University of Washington, Seattle, WA 98195, USA.
Lishan HuangDepartment of Medicine, Division of Medical Genetics, University of Washington, Seattle, WA 98195, USA.
Audrey GermondWashington National Primate Research Center, Division of Regenerative Medicine and Gene Therapy, Seattle, WA 98195, USA.
Audrey BaldessariWashington National Primate Research Center, Division of Regenerative Medicine and Gene Therapy, Seattle, WA 98195, USA.
Veronica NelsonStem and Gene Therapy Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Katharine J BarPerelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Christopher W PetersonStem and Gene Therapy Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Washington National Primate Research Center, Division of Regenerative Medicine and Gene Therapy, Seattle, WA 98195, USA.
John BuiStem and Gene Therapy Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Department of Medicine, Division of Allergy and Infection Diseases, University of Washington, Seattle, WA 98195, USA.
Hans-Peter KiemStem and Gene Therapy Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Washington National Primate Research Center, Division of Regenerative Medicine and Gene Therapy, Seattle, WA 98195, USA; Department of Medicine, Division of Medical Oncology, University of Washington, Seattle, WA 98195, USA.
André LieberDepartment of Medicine, Division of Medical Genetics, University of Washington, Seattle, WA 98195, USA; Washington National Primate Research Center, Division of Regenerative Medicine and Gene Therapy, Seattle, WA 98195, USA. Electronic address: lieber00@uw.edu.
University of Washington Medical Center · USFred Hutch Cancer Center · USUniversity of Pennsylvania · USUniversity of Washington · US

Funding

Washington National Primate Research CenterP51OD010425 · OD · UNIVERSITY OF WASHINGTON · PI Mari Ostendorf · 2012 to 2026
$201.8M
VENEREAL DISEASET32AI007140 · NIAID · UNIVERSITY OF WASHINGTON · PI Julia Cook Dombrowski · 1985 to 2026
$19.4M
In Vivo Hematopoietic Stem Cell Gene Therapy of Beta-Thalassemia and Sickle Cell DiseaseR01HL130040 · NHLBI · UNIVERSITY OF WASHINGTON · PI LIEBER, ANDRE MICHAEL · 2016 to 2024
$4.3M
In vivo HSC gene therapy using a multi-modular HDAd vector for HIV cureR01AI174304 · NIAID · UNIVERSITY OF WASHINGTON · PI HANS-PETER KIEM, ANDRE Michael LIEBER · 2023 to 2026
$4.3M
Approach for in vivo gene delivery into hematopoietic stem cells for hemophilia A therapyR01HL141781 · NHLBI · UNIVERSITY OF WASHINGTON · PI LIEBER, ANDRE MICHAEL · 2018 to 2021
$2.3M
NHLBI NIH HHS R01 HL130040NHLBI NIH HHS R01 HL141781NIAID NIH HHS R01 AI174304NIAID NIH HHS T32 AI007140NIH HHS P51 OD010425
6 · The paper itself

Abstract

We aim to develop an in vivo hematopoietic stem cell (HSC) gene therapy approach for persistent control/protection of HIV-1 infection based on the stable expression of a secreted decoy protein for HIV receptors CD4 and CCR5 (eCD4-Ig) from blood cells. HSCs in mice and a rhesus macaque were mobilized from the bone marrow and transduced by an intravenous injection of HSC-tropic, integrating HDAd5/35++ vectors expressing rhesus eCD4-Ig. In vivo HSC transduction/selection resulted in stable serum eCD4-Ig levels of ∼100 μg/mL (mice) and >20 μg/mL (rhesus) with half maximal inhibitory concentrations (IC

Indexed as

HIV-1HIV InfectionsSimian Acquired Immunodeficiency SyndromeSimian Immunodeficiency VirusAnimalsHematopoietic Stem CellsHumansMacaca mulattaMiceeCD4-Ig decoy receptorgene therapyhelper-dependent adenovirus vectorshematopoietic stem cellsin vivomobilizationrhesus macaquessimian-human immunodeficiency virus

Identifiers

PMID36760126
PMCPMC10124088
OpenAlexW4319766290

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.