Evidence map›Paper›PMID 36760125›Full record

ArticleBiophysical journal2023

Gating kinetics and pharmacological properties of small-conductance Ca

Ilsbeth G M van Herck, Vincent Seutin, Bo H Bentzen, Neil V Marrion, Andrew G Edwards

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biophysical journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 5 institutions in 5 countries.

Ilsbeth G M van HerckComputational Physiology Department, Simula Research Laboratory, Oslo, Norway; Institute of Informatics, University of Oslo, Oslo, Norway.
Vincent SeutinNeurophysiology Unit, GIGA Neurosciences, University of Liège, Liège, Belgium.
Bo H BentzenAcesion Pharma, Copenhagen, Denmark; Biomedical Institute, University of Copenhagen, Copenhagen, Denmark.
Neil V MarrionSchool of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, UK.
Andrew G EdwardsComputational Physiology Department, Simula Research Laboratory, Oslo, Norway; Department of Pharmacology, University of California, Davis, California. Electronic address: andy@simula.no.
Simula Research Laboratory · NOUniversity of Bristol · GBUniversity of Copenhagen · DKUniversity of Liège · BEUniversity of Oslo · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Small-conductance (SK) calcium-activated potassium channels are a promising treatment target in atrial fibrillation. However, the functional properties that differentiate SK inhibitors remain poorly understood. The objective of this study was to determine how two unrelated SK channel inhibitors, apamin and AP14145, impact SK channel function in excised inside-out single-channel recordings. Surprisingly, both apamin and AP14145 exert much of their inhibition by inducing a class of very-long-lived channel closures (apamin: τ

Indexed as

Potassium ChannelsSmall-Conductance Calcium-Activated Potassium ChannelsAcetamidesApaminCalciumKineticsAcetamidesAP14145ApaminCalciumPotassium ChannelsSmall-Conductance Calcium-Activated Potassium Channels

Identifiers

PMID36760125
PMCPMC10111258
OpenAlexW4319771376

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.