Evidence map›Paper›PMID 36760117›Full record

ReviewEuropean journal of ophthalmology2023

Ocular complications of plasma cell dyscrasias.

Rohan Bir Singh, Sachi Singhal, Shruti Sinha, Junsang Cho, Anne Xuan-Lan Nguyen, Lovedeep Singh Dhingra, Snimarjot Kaur, Vasudha Sharma, Aniruddha Agarwal

Open access · hybridAbstract readReview
In one paragraph

Review in European journal of ophthalmology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 6 countries.

Rohan Bir SinghMassachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-2426-3900
Sachi SinghalDepartment of Internal Medicine, Crozer-Chester Medical Center, Upland, PA, USA.
Shruti SinhaMassachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.
Junsang ChoDepartment of Ophthalmology, Vanderbilt Eye Center, Vanderbilt University Medical Center, Nashville, TN, USA.
Anne Xuan-Lan NguyenFaculty of Medicine, McGill University, Montreal, Canada.ORCID 0000-0002-3999-946X
Lovedeep Singh DhingraCenter for Outcomes Research and Evaluation, Yale-New Haven Hospital, New Haven, CT, USA.ORCID 0000-0002-5664-4126
Snimarjot KaurDepartment of Pediatrics, Yale-New Haven Hospital, New Haven, CT, USA.
Vasudha SharmaDepartment of Internal Medicine, Dayanand Medical College and Hospital, Ludhiana, India.ORCID 0000-0002-5295-2375
Aniruddha AgarwalDepartment of Ophthalmology, University of Maastricht, Maastricht, the Netherlands.
Massachusetts Eye and Ear Infirmary · USYale New Haven Hospital · USCrozer-Keystone Health System · USDayanand Medical College & Hospital · INMaastricht University · NLMcGill University · CAVanderbilt University Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Plasma cell dyscrasias are a wide range of severe monoclonal gammopathies caused by pre-malignant or malignant plasma cells that over-secrete an abnormal monoclonal antibody. These disorders are associated with various systemic findings, including ophthalmological disorders. A search of PubMed, EMBASE, Scopus and Cochrane databases was performed in March 2021 to examine evidence pertaining to ocular complications in patients diagnosed with plasma cell dyscrasias. This review outlines the ocular complications associated with smoldering multiple myeloma and monoclonal gammopathy of undetermined significance, plasmacytomas, multiple myeloma, Waldenström's macroglobulinemia, systemic amyloidosis, Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal gammopathy and Skin changes (POEMS) syndrome, and cryoglobulinemia. Although, the pathological mechanisms are not completely elucidated yet, wide-ranging ocular presentations have been identified over the years, evolving both the anterior and posterior segments of the eye. Moreover, the presenting symptoms also help in early diagnosis in asymptomatic patients. Therefore, it is imperative for the treating ophthalmologist and oncologist to maintain a high clinical suspicion for identifying the ophthalmological signs and diagnosing the underlying disease, preventing its progression through efficacious treatment strategies.

Indexed as

Eye DiseasesParaproteinemiasEyeHumansTreatment OutcomeCORNEA / EXTERNAL DISEASEcorneal degenerationsGLAUCOMARETINARetinal degenerations associated with systemic disease

Identifiers

PMID36760117
PMCPMC10472748
OpenAlexW4319812120

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.