Evidence map›Paper›PMID 36759887›Full record

ArticleBMC pharmacology & toxicology2023

Zinc oxide calcium silicate composite attenuates acute tramadol toxicity in mice.

Shaimaa A ElShebiney, Rania Elgohary, Sayed H Kenawy, Gehan T El-Bassyouni, Esmat M A Hamzawy

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pharmacology & toxicology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Shaimaa A ElShebineyNarcotics, Ergogenics, and Poisons Department, National Research Centre, 33-El-Buhouth St., 12622, Dokki, Giza, Egypt. sa.elshebiney@nrc.sci.eg.
Rania ElgoharyNarcotics, Ergogenics, and Poisons Department, National Research Centre, 33-El-Buhouth St., 12622, Dokki, Giza, Egypt.
Sayed H KenawyRefractories, Ceramics and Building Materials Department, National Research Centre, 33 El Buhouth St, Dokki, Giza, 12622, Egypt.
Gehan T El-BassyouniRefractories, Ceramics and Building Materials Department, National Research Centre, 33 El Buhouth St, Dokki, Giza, 12622, Egypt.
Esmat M A HamzawyGlass Research Department, National Research Centre, 33 El Buhouth St, Dokki, Giza, 12622, Egypt.
National Research Centre · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSeizures are considered to be the most common symptom encountered in emergency- rushed tramadol-poisoned patients; accounting for 8% of the drug-induced seizure cases. Although, diazepam clears these seizures, the risk of central respiratory depression cannot be overlooked. Henceforth, three adsorbing composites were examined in a tramadol acute intoxication mouse model.

methodsCalcium Silicate (Wollastonite) either non-doped or wet doped with iron oxide (3%Fe

resultsThe 3% Fe

conclusionThe calcium silicate composite doped with ZnO presented a good resolution of tramadol-induced seizures accompanied by detoxification of blood, indicating its potential for application in such cases. Further studies are required.

Indexed as

TramadolZinc OxideAnalgesics, OpioidAnimalsCalcium CompoundsMiceSeizuresSilicatesAnalgesics, OpioidCalcium Compoundscalcium silicateSilicatesTramadolZinc OxideAdsorptionAntidoteNano-microstructureSilicate phasesToxicity managementWollastonite

Identifiers

PMID36759887
PMCPMC9912638
OpenAlexW4319726982

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.