ArticleNature immunology2023
The endogenous repertoire harbors self-reactive CD4
Open access · greenAbstract read
In one paragraph
Article in Nature immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 21 citations in OpenAlex.
- Calibrating T cell responsiveness through interactions with self.Nature reviews. Immunology · 2026Review
- Ambient temperature regulates CD4iScience · 2026Article
- Germinal-centre and extrafollicular B cell pathways in systemic lupus erythematosus.Nature reviews. Rheumatology · 2026Review
- Self-Antigens Select B Cells: A New Perspective on B Cell Selection and Function.European journal of immunology · 2025Review
- Regulatory T cells constrain T cells of shared specificity to enforce tolerance during infection.Science (New York, N.Y.) · 2025Article
- Insights into regulatory T-cell and type-I interferon roles in determining abacavir-induced hypersensitivity or immune tolerance.Frontiers in immunology · 2025Article
- Breakdown and Repair of Peripheral Immune Tolerance in Type 1 Diabetes.Cold Spring Harbor perspectives in medicine · 2024Review
- Help me help you: emerging concepts in T follicular helper cell differentiation, identity, and function.Current opinion in immunology · 2024Review
- T cell help shapes B cell tolerance.Science immunology · 2024Article
- CARD11 regulates the thymic Treg development in an NF-κB-independent manner.Frontiers in immunology · 2024Article
- Microbiome Differences in Colorectal Cancer Patients and Healthy Individuals: Implications for Vaccine Antigen Discovery.ImmunoTargets and therapy · 2024Review
- Revealing the identity of regulatory T-cell-suppressed self-reactive CD4Cellular & molecular immunology · 2023Article
- Systems immunology of regulatory T cells: can one circuit explain it all?Trends in immunology · 2023Review
- Renegade T cell clones and autoimmune disease.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Germline-mediated immunoediting sculpts breast cancer subtypes and metastatic proclivity.bioRxiv : the preprint server for biology · 2023Article
- Lineage origin and transcriptional control of autoantigen-specific T-regulatory type 1 cells.Frontiers in immunology · 2023Review
Corrections and comments
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Authors and funding
15 authors at 5 institutions in 1 country.
Victoria Lee *Interdisciplinary Scientist Training Program, University of Chicago, Chicago, IL, USA.
Donald M Rodriguez *Interdisciplinary Scientist Training Program, University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0002-2534-1480
Nicole K GanciCommittee on Immunology, University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0002-8037-607X
Sharon ZengDepartment of Pathology, University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0001-7150-1345
Junting AiSection of Rheumatology, Department of Medicine and Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Chicago, IL, USA.
Jaime L ChaoCommittee on Immunology, University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0003-1872-734X
Matthew T WalkerCommittee on Immunology, University of Chicago, Chicago, IL, USA.
Christine H MillerInterdisciplinary Scientist Training Program, University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0003-2176-9516
David E J KlawonCommittee on Immunology, University of Chicago, Chicago, IL, USA.
Mary H SchoenbachDepartment of Pathology, University of Chicago, Chicago, IL, USA.
Domenick E KennedySection of Rheumatology, Department of Medicine and Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Chicago, IL, USA.
Mark Maienschein-ClineResearch Informatics Core, Research Resources Center, University of Illinois at Chicago, Chicago, IL, USA.
Nicholas D SocciBioinformatics Core, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Marcus R ClarkSection of Rheumatology, Department of Medicine and Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Chicago, IL, USA.
Peter A SavageDepartment of Pathology, University of Chicago, Chicago, IL, USA. psavage@bsd.uchicago.edu.ORCID http://orcid.org/0000-0002-2506-7717
University of Chicago · USAbbVie (United States) · USMemorial Sloan Kettering Cancer Center · USUniversity of Illinois Chicago · USUniversity of Washington · US
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4MVIRAL ONCOLOGY CORE FACILITYP30CA014599 · NCI · UNIVERSITY OF CHICAGO · PI CHIEN-MIN KAO · 1985 to 2026
$122.1MStrengthening Stakeholder Engagement in Human Research Protections.UL1TR002003 · NCATS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI KARNIK, NIRANJAN SUBHASH, MERMELSTEIN, ROBIN J. · 2016 to 2024
$33.7MMEDICAL SCIENTIST TRAININGT32GM007281 · NIGMS · UNIVERSITY OF CHICAGO · PI CLARK, MARCUS RAMSAY · 1985 to 2022
$32.1MINTERDISCIPLINARY TRAINING PROGRAM IN IMMUNOLOGYT32AI007090 · NIAID · UNIVERSITY OF CHICAGO · PI Peter Aidan Savage · 1985 to 2026
$11.7MRole of CXCR4 in immunoglobulin light chain recombinationR01AI150860 · NIAID · UNIVERSITY OF CHICAGO · PI CLARK, MARCUS RAMSAY, MANDAL, MALAY · 2021 to 2025
$2.9MThe epigenetic reader BRWD1 in peripheral adaptive immunityR01AI143778 · NIAID · UNIVERSITY OF CHICAGO · PI CLARK, MARCUS RAMSAY · 2019 to 2023
$2.4MSpecificity of regulatory T cell suppression during infectionU01AI154560 · NIAID · UNIVERSITY OF CHICAGO · PI SAVAGE, PETER AIDAN · 2021 to 2025
$2.0MFunction of Aire-dependent regulatory T cells in immune toleranceR01AI110507 · NIAID · UNIVERSITY OF CHICAGO · PI SAVAGE, PETER AIDAN · 2015 to 2019
$1.7MDevelopment and specificity of endogeneous tumor-infiltrating regulatory T cellsR01CA160371 · NCI · UNIVERSITY OF CHICAGO · PI SAVAGE, PETER AIDAN · 2011 to 2015
$1.6MDefining tolerance mechanisms regulating self-specific T cellsF30CA217109 · NCI · UNIVERSITY OF CHICAGO · PI LEE, VICTORIA · 2017 to 2021
$250kSpecificity and function of memory-phenotype CD8+ T cells in the tumor environmentF30CA236061 · NCI · UNIVERSITY OF CHICAGO · PI MILLER, CHRISTINE · 2019 to 2022
$203kNCATS NIH HHS UL1 TR002003NCI NIH HHS F30 CA217109NCI NIH HHS F30 CA236061NCI NIH HHS F30 CA247264NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA014599NCI NIH HHS R01 CA160371NIAID NIH HHS R01 AI110507NIAID NIH HHS R01 AI143778NIAID NIH HHS R01 AI150860NIAID NIH HHS T32 AI007090NIAID NIH HHS U01 AI154560NIGMS NIH HHS T32 GM007281
Abstract
The T cell repertoire of healthy mice and humans harbors self-reactive CD4
Indexed as
CD4-Positive T-LymphocytesT Follicular Helper CellsT-Lymphocytes, RegulatoryAnimalsAutoimmunityCell DifferentiationClone CellsHumansMicePhenotypeT-Lymphocytes, Helper-Inducer
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.