ArticleScientific reports2023
Detection of a reduced susceptibility to chlorfenapyr in the malaria vector Anopheles gambiae contrasts with full susceptibility in Anopheles funestus across Africa.
Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Chlorfenapyr-pyrethroid nets for pyrethroid-resistant malaria vectors: efficacy, resistance risks, and policy implications.Global health action · 2026Pooled it
- Modelling the impact of adopting new-generation insecticide-treated nets on malaria transmission and insecticide resistance.Parasites & vectors · 2026Article
- Sublethal effects of insecticides on the reproduction traits of insecticide-resistant Anopheles gambiae sensu lato mosquitoes from Tiassalé, Côte d'Ivoire.Parasites & vectors · 2026Article
- Signature of resistance gene evolution and pyrethroid resistance escalation in the major malaria vector Anopheles funestus across Kenyan malaria-endemic regions separated by the Rift Valley.Infectious diseases of poverty · 2026Article
- The Ifakara Ambient Chamber Test (I-ACT) for Evaluation of Indoor Residual Sprays: A Non-Inferiority Test of SylandoInsects · 2026Article
- Chlorfenapyr bednets effectively overcome pyrethroid resistance escalation in highly resistant Anopheles malaria vectors in Uganda.Scientific reports · 2026Article
- Turning the tide against malaria in high-burden African countries: Trends, threats, and solutions.PLOS global public health · 2026Article
- Trends and patterns of insecticide susceptibility of Anopheles gambiae between 2015 and 2020: implications for malaria vector control interventions in Ghana.Malaria journal · 2025Article
- Managing insecticide resistance in malaria vectors in Africa: case studies from Cameroon, Côte d'Ivoire and Tanzania.Malaria journal · 2025Article
- Environmental contaminants drive insecticide resistance in Anopheles mosquitoes in Ghana.Scientific reports · 2025Article
- Long-term impact of exposure to Royal Guard, a pyriproxyfen-based bed net, on pyrethroid-resistant malaria vectors from Cameroon using DNA-based metabolic resistance markers.Pest management science · 2025Article
- Determination of the residual efficacy of broflanilide (VECTRON™ T500) insecticide for indoor residual spraying in a semi-field setting in Ethiopia.Malaria journal · 2025Article
- The epidemiological benefit of pyrethroid-pyrrole insecticide treated nets against malaria: an individual-based malaria transmission dynamics modelling study.The Lancet. Global health · 2024Article
- Substrate promiscuity of key resistance P450s confers clothianidin resistance while increasing chlorfenapyr potency in malaria vectors.Cell reports · 2024Article
- Functional Validation of Endogenous Redox PartnerInternational journal of molecular sciences · 2024Article
- The P450-Monooxygenase Activity and CYP6D1 Expression in the Chlorfenapyr-Resistant Strain ofInsects · 2024Article
- IsCurrent research in parasitology & vector-borne diseases · 2024Article
- Insecticidal roof barriers mounted on untreated bed nets can be as effective against Anopheles gambiae as regular insecticide-treated bed nets.Scientific reports · 2023Article
- Sub-lethal exposure to chlorfenapyr reduces the probability of developing Plasmodium falciparum parasites in surviving Anopheles mosquitoes.Parasites & vectors · 2023Article
- Chlorfenapyr metabolism by mosquito P450s associated with pyrethroid resistance identifies potential activation markers.Scientific reports · 2023Article
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Authors and funding
12 authors at 7 institutions in 6 countries.
Funding
Abstract
New insecticides have recently been produced to help control pyrethroid-resistant malaria vectors including the pyrrole, chlorfenapyr. Monitoring the susceptibility of mosquito populations against this new product and potential cross-resistance with current insecticides is vital for better resistance management. In this study, we assessed the resistance status of the major malaria vectors Anopheles gambiae and Anopheles funestus to chlorfenapyr across Africa and explored potential cross-resistance with known pyrethroid resistance markers. Efficacy of chlorfenapyr 100 µg/ml against An. gambiae and An. funestus from five Cameroonian locations, the Democratic Republic of Congo, Ghana, Uganda, and Malawi was assessed using CDC bottle assays. Synergist assays were performed with PBO (4%), DEM (8%) and DEF (0.25%) and several pyrethroid-resistant markers were genotyped in both species to assess potential cross-resistance between pyrethroids and chlorfenapyr. Resistance to chlorfenapyr was detected in An. gambiae populations from DRC (Kinshasa) (mortality rate: 64.3 ± 7.1%) Ghana (Obuasi) (65.9 ± 7.4%), Cameroon (Mangoum; 75.2 ± 7.7% and Nkolondom; 86.1 ± 7.4). In contrast, all An. funestus populations were fully susceptible. A negative association was observed between the L1014F-kdr mutation and chlorfenapyr resistance with a greater frequency of homozygote resistant mosquitoes among the dead mosquitoes after exposure compared to alive (OR 0.5; P = 0.02) whereas no association was found between GSTe2 (I114T in An. gambiae; L119F in An. funestus) and resistance to chlorfenapyr. A significant increase of mortality to chlorfenapyr 10 µg/ml was observed in An. funestus after to PBO, DEM and DEF whereas a trend for a decreased mortality was observed in An. gambiae after PBO pre-exposure. This study reveals a greater risk of chlorfenapyr resistance in An. gambiae populations than in An. funestus. However, the higher susceptibility in kdr-resistant mosquitoes points to higher efficacy of chlorfenapyr against the widespread kdr-based pyrethroid resistance.
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