Evidence map›Paper›PMID 36759538›Full record

ArticleScientific reports2023

Somatostatin slows Aβ plaque deposition in aged APP

Declan Williams, Bei Qi Yan, Hansen Wang, Logine Negm, Christopher Sackmann, Claire Verkuyl, Vanessa Rezai-Stevens, Shehab Eid, Nimit Vediya, Christine Sato and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Declan WilliamsTanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.
Bei Qi YanTanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.
Hansen WangTanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.
Logine NegmTanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.
Christopher SackmannTanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.
Claire VerkuylTanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.
Vanessa Rezai-StevensTanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.
Shehab EidTanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.
Nimit VediyaTanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.
Christine SatoTanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.
Joel C WattsTanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.
Holger WilleCentre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, AB, Canada.
Gerold Schmitt-UlmsTanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada. g.schmittulms@utoronto.ca.
Occupational Cancer Research Centre · CAUniversity of Toronto · CAUniversity of Alberta · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The neuroendocrine peptide somatostatin (SST) has long been thought of as influencing the deposition of the amyloid β peptide (Aβ) in Alzheimer's disease (AD). Missing have been in vivo data in a relevant Aβ amyloidosis model. Here we crossed App

Indexed as

Alzheimer DiseaseAmyloidosisAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAnimalsDisease Models, AnimalMiceMice, TransgenicNeprilysinPlaque, AmyloidSomatostatinAmyloid beta-PeptidesAmyloid beta-Protein PrecursorNeprilysinSomatostatin

Identifiers

PMID36759538
PMCPMC9911728
OpenAlexW4319741974

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.