ArticleNPJ Parkinson's disease2023
Genome-wide association study using whole-genome sequencing identifies risk loci for Parkinson's disease in Chinese population.
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Article in NPJ Parkinson's disease, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
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37citing papers in PubMed, 1 pooled it
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.
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- Genetic Variants and Clinical Characteristics of Young-Onset Parkinson's Disease in the Hakka Population of Western Fujian.Brain and behavior · 2026Article
- Distinct UNC13A Haplotype Blocks Define Disease Severity and Survival in Chinese Amyotrophic Lateral Sclerosis.European journal of neurology · 2026Article
- Novel associations of VPS13C with phenotype and conversion of idiopathic REM sleep behavior disorder.NPJ Parkinson's disease · 2026Article
- Large-scale profiling of blood microbial signatures in patients with Parkinson's disease and its association with disease progression: a cross-sectional study.EBioMedicine · 2026Article
- The genetic spectrum of LRRK2 variants in Parkinson's disease: findings from a large Chinese cohort.NPJ Parkinson's disease · 2026Article
- Genetic risk loci for Parkinson's disease and dementia in a large-scale population-based Taiwanese cohort (TPMI).The Lancet regional health. Western Pacific · 2026Article
- LRRK2NPJ Parkinson's disease · 2026Article
- Association of LRRK2 p.A419V with Parkinson's Disease in East Asians and analysis of age at onset.NPJ Parkinson's disease · 2026Article
- Role of Microglial Dysfunction in Parkinson's Disease: From Multifactorial Causes to Neurodegeneration.Neuroscience bulletin · 2026Review
- AXIN1 Polymorphisms Potentially Modulate Parkinson's Disease Susceptibility: A Cross-Sectional Study in Northern Han Chinese and White Populations.Neurology and therapy · 2026Article
- Survival and related factors in patients with Parkinson's disease: a multicenter prospective cohort study in China.Journal of neurology · 2026Article
- The Evolution of Gene Sequencing Technologies: Unveiling Genetic Architecture of Nonsyndromic Orofacial Clefts.Genetics research · 2026Review
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- Identification and validation of shared key genes between Parkinson's disease and erectile dysfunction: a bioinformatics approach.Hereditas · 2025Article
- Parkinson disease is a fatty acidopathy.Nature reviews. Neurology · 2025Review
- The APOE ε4 allele affects the survival of patients with Parkinson's disease independent of dementia.Journal of translational medicine · 2025Article
- Demographic and Clinical Profiles of Parkinson's Disease in India: Observations from a Nation-Wide Multicenter Study.Movement disorders : official journal of the Movement Disorder Society · 2025Article
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Authors and funding
61 authors at 16 institutions in 3 countries.
Hongxu Pan *Department of Neurology, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China.
Zhenhua Liu *Department of Neurology, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China.
Jinghong MaDepartment of Neurology, National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital of Capital Medical University, 100053, Beijing, China.
Yuanyuan LiDepartment of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 200025, Shanghai, China.ORCID http://orcid.org/0000-0003-4967-3890
Yuwen ZhaoDepartment of Neurology, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China.
Xiaoxia ZhouDepartment of Neurology, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China.
Yaqin XiangDepartment of Neurology, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China.
Yige WangDepartment of Neurology, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China.
Xun ZhouDepartment of Neurology, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China.
Runcheng HeDepartment of Neurology, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China.
Yali XieNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China.
Qiao ZhouNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China.
Kai YuanNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China.
Qian XuDepartment of Neurology, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China.
Qiying SunDepartment of Geriatrics, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China.
Junling WangDepartment of Neurology, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China.
Xinxiang YanDepartment of Neurology, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China.
Hainan ZhangDepartment of Neurology, The Second Xiangya Hospital, Central South University, 410011, Changsha, Hunan, China.
Chunyu WangDepartment of Neurology, The Second Xiangya Hospital, Central South University, 410011, Changsha, Hunan, China.
Lifang LeiDepartment of Neurology, The Third Xiangya Hospital, Central South University, 410013, Changsha, Hunan, China.
Weiguo LiuDepartment of Neurology, Affiliated Brain Hospital of Nanjing Medical University, 210029, Nanjing, Jiangsu, China.
Xuejing WangDepartment of Neurology, The First Affiliated Hospital of Zhengzhou University, 450047, Zhengzhou, Henan, China.
Xuebing DingDepartment of Neurology, The First Affiliated Hospital of Zhengzhou University, 450047, Zhengzhou, Henan, China.
Tao WangDepartment of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430022, Wuhan, Hubei, China.
Zheng XueDepartment of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, Hubei, China.
Zhentao ZhangDepartment of Neurology, Renmin Hospital of Wuhan University, 430060, Wuhan, Hubei, China.ORCID http://orcid.org/0000-0001-6708-1472
Ling ChenDepartment of Neurology, First Affiliated Hospital, Sun Yat-sen University, 510080, Guangzhou, Guangdong, China.
Qing WangDepartment of Neurology, Zhujiang Hospital of Southern Medical University, 510280, Guangzhou, Guangdong, China.
Yonghong LiuHealth Management Center, Hunan Provincial Brain Hospital, 410021, Changsha, Hunan, China.
Jiayu TangDepartment of Neurology, Hunan Provincial Brain Hospital, 410021, Changsha, Hunan, China.
Xuewei ZhangDepartment of Health Management Center, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China.
Shifang PengDepartment of Health Management Center, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China.
Chaodong WangDepartment of Neurology, National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital of Capital Medical University, 100053, Beijing, China.
Jianqing DingInstitute of Aging & Tissue Regeneration, Renji Hospital, Shanghai Jiao Tong University School of Medicine, 200025, Shanghai, China.
Chunfeng LiuDepartment of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, 215004, Suzhou, Jiangsu, China.ORCID http://orcid.org/0000-0002-8364-0219
Lijuan WangDepartment of Neurology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, 510080, Guangzhou, Guangdong, China.
Haibo ChenDepartment of Neurology, National Center of Gerontology, Beijing Hospital, 100005, Beijing, China.
Lu ShenDepartment of Neurology, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China.
Hong JiangDepartment of Neurology, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China.
Xinyin WuDepartment of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, 410028, Changsha, Hunan, China.
Hongzhuan TanDepartment of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, 410028, Changsha, Hunan, China.
Dan LuoDepartment of Social Medicine and Health Management, Xiangya School of Public Health, Central South University, 410028, Changsha, Hunan, China.
Shuiyuan XiaoDepartment of Social Medicine and Health Management, Xiangya School of Public Health, Central South University, 410028, Changsha, Hunan, China.
Xiang ChenThe Department of Dermatology, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China.
Jieqiong TanCentre for Medical Genetics & Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, 410012, Changsha, Hunan, China.
Zhengmao HuCentre for Medical Genetics & Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, 410012, Changsha, Hunan, China.
Chao ChenCentre for Medical Genetics & Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, 410012, Changsha, Hunan, China.ORCID http://orcid.org/0000-0002-5114-2282
Kun XiaCentre for Medical Genetics & Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, 410012, Changsha, Hunan, China.
Zhuohua ZhangHunan Key Laboratory of Molecular Precision Medicine, Department of Oncology, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China.
Jia Nee FooLee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, 308232, Singapore.
Cornelis BlauwendraatMolecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, 20892, USA.ORCID http://orcid.org/0000-0001-9358-8111
Mike A NallsMolecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, 20892, USA.
Andrew B SingletonMolecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, 20892, USA.ORCID http://orcid.org/0000-0001-5606-700X
Jun LiuDepartment of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 200025, Shanghai, China.ORCID http://orcid.org/0000-0001-8300-8646
Piu ChanDepartment of Neurology, National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital of Capital Medical University, 100053, Beijing, China.
Houfeng ZhengDiseases & Population (DaP) Geninfo Lab, School of Life Sciences, Westlake University, 310024, Hangzhou, Zhejiang, China.ORCID http://orcid.org/0000-0001-5681-8598
Jinchen LiDepartment of Neurology, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China.
Jifeng GuoDepartment of Neurology, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China.ORCID http://orcid.org/0000-0002-3658-3928
Jian YangSchool of Life Sciences, Westlake University, 310024, Hangzhou, Zhejiang, China. jian.yang@westlake.edu.cn.ORCID http://orcid.org/0000-0003-2001-2474
Beisha TangDepartment of Neurology, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China. bstang7398@163.com.ORCID http://orcid.org/0000-0003-2120-1576
Parkinson’s Disease & Movement Disorders Multicenter Database and Collaborative Network in China (PD-MDCNC)
Central South University · CNCapital Medical University · CNNational Institutes of Health · USShanghai Jiao Tong University · CNFirst Affiliated Hospital of Zhengzhou University · CNSecond People Hospital of Hunan · CNWestlake University · CNBeijing Hospital · CNGuangdong Academy of Medical Sciences · CNNanjing Brain Hospital · CNNanyang Technological University · SGSoochow University · CNSun Yat-sen University · CNTongji Hospital · CNUnion Hospital · CNZhujiang Hospital · CN
Funding
Genetic characterization of atypical parkinsonismZIANS003154 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI SCHOLZ, SONJA · 2016 to 2025
$15.4MGenome wide SNP analysis in Parkinson's diseaseZ01AG000949 · NIA · NATIONAL INSTITUTE ON AGING · PI SINGLETON, ANDREW B · 2006 to 2008
$2.6MProspective studies on Parkinson's diseaseZ01ES101986 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI CHEN, HONGLEI · 2006 to 2008
$1.2MIntramural NIH HHS Z01 AG000949Intramural NIH HHS Z01 ES101986Intramural NIH HHS ZIA NS003154
Abstract
Genome-wide association studies (GWASs) have identified numerous susceptibility loci for Parkinson's disease (PD), but its genetic architecture remains underexplored in populations of non-European ancestry. To identify genetic variants associated with PD in the Chinese population, we performed a GWAS using whole-genome sequencing (WGS) in 1,972 cases and 2,478 controls, and a replication study in a total of 8209 cases and 9454 controls. We identified one new risk variant rs61204179 (P
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