Evidence map›Paper›PMID 36759189›Full record

ArticleeNeuro2023

Neurovascular Development in

Mary Dusing, Candi L LaSarge, Angela White, Lilian G Jerow, Christina Gross, Steve C Danzer

Open access · goldAbstract read
In one paragraph

Article in eNeuro, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Focal postnatal deletion ofFrontiers in molecular neuroscience · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Mary DusingDepartment of Anesthesia, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229.
Candi L LaSargeDepartment of Anesthesia, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229.
Angela WhiteDivision of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229.
Lilian G JerowNeuroscience Graduate Program, University of Cincinnati, Cincinnati, OH 45219.
Christina GrossDivision of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229.ORCID 0000-0001-6057-2527
Steve C DanzerDepartment of Anesthesia, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229 steve.danzer@cchmc.org.ORCID 0000-0003-4405-2999
Cincinnati Children's Hospital Medical Center · USUniversity of Cincinnati · US

Funding

Selective disruption of hippocampal dentate granule cells in autism: impact of PTR01NS065020 · NINDS · CINCINNATI CHILDRENS HOSP MED CTR · PI DANZER, STEVE C · 2009 to 2023
$6.1M
mTOR regulation of aberrant neuronal integration and epileptogenesis in epilepsyR01NS062806 · NINDS · CINCINNATI CHILDRENS HOSP MED CTR · PI DANZER, STEVE C · 2009 to 2019
$3.6M
Anti-epileptogenic role of mTOR activation among hippocampal interneuronsR01NS121042 · NINDS · CINCINNATI CHILDRENS HOSP MED CTR · PI DANZER, STEVE C · 2022 to 2025
$2.0M
Mechanism-targeted treatment strategy in PTEN-associated autism and epilepsyR21HD093033 · NICHD · CINCINNATI CHILDRENS HOSP MED CTR · PI GROSS, CHRISTINA · 2018 to 2019
$453k
Contribution of abnormal granule cells to the development of an epileptic hippocaF32NS083239 · NINDS · CINCINNATI CHILDRENS HOSP MED CTR · PI LASARGE, CANDI LYNN · 2013 to 2013
$49k
NICHD NIH HHS R21 HD093033NINDS NIH HHS F32 NS083239NINDS NIH HHS R01 NS062806NINDS NIH HHS R01 NS065020NINDS NIH HHS R01 NS121042
6 · The paper itself

Abstract

Hyperactivation of the mechanistic target of rapamycin (mTOR) signaling pathway is linked to more than a dozen neurologic diseases, causing a range of pathologies, including excess neuronal growth, disrupted neuronal migration, cortical dysplasia, epilepsy and autism. The mTOR pathway also regulates angiogenesis. For the present study, therefore, we queried whether loss of

Indexed as

EpilepsyTOR Serine-Threonine KinasesAnimalsMiceNeuronsProsencephalonPTEN PhosphohydrolaseSignal TransductionSirolimusTuberous Sclerosis Complex 2 ProteinPTEN PhosphohydrolaseSirolimusTOR Serine-Threonine KinasesTsc2 protein, mouseTuberous Sclerosis Complex 2 Proteinangiogenesisfocal cortical dysplasiamTORmtoropathytuberous sclerosisVegf

Identifiers

PMID36759189
PMCPMC9953070
OpenAlexW4319663010

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.