Evidence map›Paper›PMID 36759130›Full record

ArticleAmerican journal of physiology. Renal physiology2023

Reactivity of renal and mesenteric resistance vessels to angiotensin II is mediated by NOXA1/NOX1 and superoxide signaling.

Mark D Stevenson, Aleksandr E Vendrov, Xi Yang, Yuenmu Chen, Hernán A Navarro, Nicholas Moss, Marschall S Runge, William J Arendshorst, Nageswara R Madamanchi

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Mark D StevensonDivision of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States.
Aleksandr E VendrovDivision of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States.ORCID 0000-0003-4971-8040
Xi YangDepartment of Cell Biology and Physiology, University of North Carolina, Chapel Hill, North Carolina, United States.
Yuenmu ChenMcAllister Heart Institute, Division of Cardiology, Department of Medicine, University of North Carolina, Chapel Hill, North Carolina, United States.
Hernán A NavarroCenter for Drug Discovery, Organic and Medicinal Chemistry, RTI International, Research Triangle Park, North Carolina, United States.
Nicholas MossDepartment of Cell Biology and Physiology, University of North Carolina, Chapel Hill, North Carolina, United States.
Marschall S RungeDivision of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States.ORCID 0000-0002-6665-4029
William J ArendshorstDepartment of Cell Biology and Physiology, University of North Carolina, Chapel Hill, North Carolina, United States.
Nageswara R MadamanchiDivision of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States.ORCID 0000-0003-0590-0908
Michigan United · USUniversity of North Carolina at Chapel Hill · USRTI International · US

Funding

Nox1/NoxA1 Regulation of Vascular Reactivity and Sodium Excretion in Health and Hypertension.R01HL139842 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ARENDSHORST, WILLIAM J, MADAMANCHI, NAGESWARA R · 2018 to 2021
$2.9M
NHLBI NIH HHS R01 HL139842
6 · The paper itself

Abstract

Activation of NADPH oxidase (NOX) enzymes and the generation of reactive oxygen species and oxidative stress regulate vascular and renal function and contribute to the pathogenesis of hypertension. The present study examined the role of NOXA1/NOX1 function in vascular reactivity of renal and mesenteric resistance arteries/arterioles of wild-type and

Indexed as

HypertensionSuperoxidesAdaptor Proteins, Signal TransducingAngiotensin IIAnimalsKidneyMiceNADPH Oxidase 1NADPH OxidasesAdaptor Proteins, Signal TransducingAngiotensin IINADPH Oxidase 1NADPH OxidasesNOX1 protein, mouseNoxa1 protein, mouseSuperoxidesnitric oxideNoxa1−/− micereactive oxygen speciesthromboxane A2 receptorU46619

Identifiers

PMID36759130
PMCPMC10026993
OpenAlexW4319659827

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.