SynthesisCerebral cortex (New York, N.Y. : 1991)2023
Examination of common and unique brain regions for atypical reading and math: a meta-analysis.
Synthesis in Cerebral cortex (New York, N.Y. : 1991), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Neurodevelopmental commonalities in cognitive control networks for mathematics and reading in meta-analysis of 3308 participants.Nature communications · 2025Pooled it
- Human neural correlates of emotional well-being (EWB): a preliminary systematic review and meta-analysis of MRI studies based on a recent consensus definition.Frontiers in human neuroscience · 2025Pooled it
- Prismatic adaptation coupled with cognitive training as novel treatment for developmental dyslexia: a randomized controlled trial.Scientific reports · 2024Trial
- The interplay between executive function and learning disabilities: Developmental cognitive neuroscience perspectives on reading, math, and ADHD.Developmental cognitive neuroscience · 2026Review
- Individual differences in the activity of executive function brain regions during number comparison.Behavioural brain research · 2025Article
- Children identified for classroom-based math support show altered resting-state connectivity in parietal brain regions.Scientific reports · 2025Article
- Clinical implications of brain asymmetries.Nature reviews. Neurology · 2024Review
- Action video games normalise the phonemic awareness in pre-readers at risk for developmental dyslexia.NPJ science of learning · 2024Article
- Neurocognitive mechanisms of co-occurring math difficulties in dyslexia: Differences in executive function and visuospatial processing.Developmental science · 2024Article
- Activation and functional connectivity of cerebellum during reading and during arithmetic in children with combined reading and math disabilities.Frontiers in neuroscience · 2024Article
- Developmental dyscalculia is not associated with atypical brain activation: A univariate fMRI study of arithmetic, magnitude processing, and visuospatial working memory.Human brain mapping · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
The purpose of this study is to identify consistencies across functional neuroimaging studies regarding common and unique brain regions/networks for individuals with reading difficulties (RD) and math difficulties (MD) compared to typically developing (TD) individuals. A systematic search of the literature, utilizing multiple databases, yielded 116 functional magnetic resonance imaging and positron emission tomography studies that met the criteria. Coordinates that directly compared TD with either RD or MD were entered into GingerALE (Brainmap.org). An activation likelihood estimate (ALE) meta-analysis was conducted to examine common and unique brain regions for RD and MD. Overall, more studies examined RD (n = 96) than MD (n = 20). Across studies, overactivation for reading and math occurred in the right insula and inferior frontal gyrus for atypically developing (AD) > TD comparisons, albeit in slightly different areas of these regions; however, inherent threshold variability across imaging studies could diminish overlying regions. For TD > AD comparisons, there were no similar or overlapping brain regions. Results indicate there were domain-specific differences for RD and MD; however, there were some similarities in the ancillary recruitment of executive functioning skills. Theoretical and practical implications for researchers and educators are discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.