ArticleJournal of the American Medical Directors Association2023
Examining the Validity and Utility of Montreal Cognitive Assessment Domain Scores for Early Neurocognitive Disorders.
Article in Journal of the American Medical Directors Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 24 citations in OpenAlex.
- Validity of the T-MoCA for Screening MCI and Dementia and Its Equivalence to the K-MoCA-22.Journal of Korean medical science · 2026Article
- Cognitive Trajectories and Associated Factors in Prostate Cancer Survivors Over a 3-Year Prospective Study.Psycho-oncology · 2026Article
- Effects on cognition of regional astrogliosis assessed byResearch square · 2026Article
- National Age- and Education-Specific Normative Data for K-MoCA Total Score, Domain Index Scores, and K-MoCA-22.Dementia and neurocognitive disorders · 2026Article
- A Scoping Review of Clinical Utility from the Montreal Cognitive Assessment Memory Index Score.Journal of geriatric psychiatry and neurology · 2026Article
- Association of MoCA-measured cognitive functions with decision-making capacity in older adults with cognitive impairment.BMC geriatrics · 2026Article
- Article
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- An Ultra-Brief Informant Questionnaire for Case Finding of Cognitive Impairment Across Diverse Literacy: Diagnostic Accuracy Study.JMIR aging · 2026Article
- Characterizing preoperative domain-specific performance on the Montreal Cognitive Assessment and exploring its associations with adverse outcomes.Anesthesiology and perioperative science · 2026Article
- Montreal Cognitive Assessment (MoCA) Scale: Strengths, Limitations, and Implication for Clinical Practice.Iranian journal of psychiatry · 2026Review
- Cerebral microbleeds on susceptibility-weighted imaging, cognitive domains, and serum neurofilament light chain in adults with hypertension.Frontiers in neurology · 2026Article
- Gender differences in post-stroke cognitive outcomes in rehabilitation: insights from MoCA domain index scores.Frontiers in neurology · 2026Observational
- Dietary n-3 Polyunsaturated Fatty Acids From Fish Are Associated With Better Healthy Aging Indicators: Results of the DIAPELH Study.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2025Article
- Limited Evidence to Review-Is There an Association Between Cognition and Upper Extremity Motor Reaction Time in Older Adults?NeuroSci · 2025Review
- A normative calculator for MoCA domain scores: proxy for Z-scores of conventional neuropsychological tests.Alzheimer's research & therapy · 2025Article
- PENSIEVE-AI a brief cognitive test to detect cognitive impairment across diverse literacy.Nature communications · 2025Article
- Relationship between neuroimaging and cognition in frontotemporal dementia: An FDG-PET and structural MRI study.Journal of neuroimaging : official journal of the American Society of NeuroimagingArticle
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
objectivesMontreal Cognitive Assessment (MoCA) total scores have been widely used to identify individuals with neurocognitive disorders (NCDs), but the utility of its domain-specific scores have yet to be thoroughly interrogated. This study aimed to validate MoCA's 6 domain-specific scores (ie, Memory, Language, Attention, Executive, Visuospatial, and Orientation) with conventional neuropsychological tests and explore whether MoCA domain scores could discriminate between different etiologies in early NCDs.
designBaseline data of a cohort study. SETTING AND
participantsStudy included 14,571 participants recruited from Alzheimer's Disease Centers across United States, aged ≥50 years, with global Clinical Dementia Rating of ≤1, and mean age of 71.8 ± 8.9 years.
methodsParticipants completed MoCA, conventional neuropsychological tests, and underwent standardized assessments to diagnose various etiologies of NCDs. Partial correlation coefficient was used to examine construct validity between Z scores of neuropsychological tests and MoCA domain scores, whereas multinomial logistic regression examined utility of domain scores to differentiate between etiologies of early NCDs.
resultsMoCA domain scores correlated stronger with equivalent constructs (r = 0.15-0.43, P < .001), and showed divergence from dissimilar constructs on neuropsychological tests. Participants with Alzheimer's disease were associated with greater impairment in Memory, Attention, Visuospatial, and Orientation domains (RRR = 1.13-1.55, P < .001). Participants with Lewy body disease were impaired in Attention and Visuospatial domains (RRR = 1.21-1.47, P < .001); participants with frontotemporal lobar degeneration were impaired in Language, Executive, and Orientation domains (RRR = 1.25-1.75, P < .01); and participants with Vascular disease were impaired in Attention domain (RRR = 1.14, P < .001). CONCLUSIONS AND IMPLICATIONS: MoCA domain scores approximate well-established neuropsychological tests and can be valuable in discriminating different etiologies of early NCDs. Although MoCA domain scores may not fully substitute neuropsychological tests, especially in the context of diagnostic uncertainties, they can complement MoCA total scores as part of systematic evaluation of early NCDs and conserve the use of neuropsychological tests to patients who are more likely to require further assessments.
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