ArticleThrombosis and haemostasis2023
Contemporary Management and Clinical Course of Acute Pulmonary Embolism: The COPE Study.
Article in Thrombosis and haemostasis, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03631810 (Contemporary Clinical Management Of Acute Pulmonary Embolism. The COPE Study), which is not on this map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Contemporary Clinical Management Of Acute Pulmonary Embolism. The COPE Study
Who cites it
16 citing papers in PubMed, 30 citations in OpenAlex.
- Trial
- Global burden of venous thromboembolism: incidence and outcome estimates of deep-vein thrombosis and pulmonary embolism.Nature reviews. Cardiology · 2026Review
- Successful management of life-threatening acute pulmonary embolism during anesthesia induction for comminuted intertrochanteric fracture surgery: a case report.Frontiers in cardiovascular medicine · 2026Article
- Preferences Among Expert Physicians in Areas of Uncertainty in Venous Thromboembolism Management: Results from a Multiple-Choice Questionnaire.Journal of clinical medicine · 2025Article
- Electrocardiographic Prediction of Acute Pulmonary Embolism at Intermediate-High- and High-Risk.Circulation reports · 2025Article
- Comparative effectiveness of suction thrombectomy versus catheter-directed thrombolysis in intermediate-risk pulmonary embolism.Journal of vascular surgery · 2025Article
- Acute Pulmonary Embolism Treated by Surgery and Complicated With a Pulmonary Artery Pseudoaneurysm: A Case Report.Cureus · 2025Article
- Use of the PaOJournal of thoracic disease · 2025Article
- Healthcare resource utilisation and associated costs after low-risk pulmonary embolism: pre-specified analysis of the Home Treatment of Pulmonary Embolism (HoT-PE) study.Clinical research in cardiology : official journal of the German Cardiac Society · 2025Article
- Implementation of Revised Simplified Geneva Score in Triage Nurse Evaluation for Patients With Suspected Pulmonary Embolism: A Retrospective Chart Review.Emergency medicine international · 2025Article
- Trends in Initial Anticoagulation Among US Patients Hospitalized With Acute Pulmonary Embolism 2011-2020.Annals of emergency medicine · 2024Article
- The Clinical Impact of the Pulmonary Embolism Severity Index on the Length of Hospital Stay of Patients with Pulmonary Embolism: A Randomized Controlled Trial.Diagnostics (Basel, Switzerland) · 2024Article
- Prevention of thromboembolism after a fracture: is aspirin enough?European heart journal supplements : journal of the European Society of Cardiology · 2024Article
- Addressing the rising trend of high-risk pulmonary embolism mortality: Clinical and research priorities.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2024Article
- Provoked vs minimally provoked vs unprovoked VTE: does it matter?Hematology. American Society of Hematology. Education Program · 2023Article
- Prevalence of and Eligibility for Surveillance Without Anticoagulation Among Adults With Lower-Risk Acute Subsegmental Pulmonary Embolism.JAMA network open · 2023Article
Corrections and comments
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Authors and funding
15 authors at 10 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNew diagnosis, risk stratification, and treatment strategies became recently available for patients with acute pulmonary embolism (PE) leading to changes in clinical practice and potentially influencing short-term patients' outcomes. RESEARCH QUESTION: The COntemporary management of PE (COPE) study is aimed at assessing the contemporary clinical management and outcomes in patients with acute symptomatic PE. STUDY DESIGN AND
methodsProspective, noninterventional, multicenter study. The co-primary study outcomes, in-hospital and 30-day death, were reported overall and by risk categories according to the European Society of Cardiology (ESC) and American Heart Association guidelines.
resultsAmong 5,213 study patients, PE was confirmed by computed tomography in 96.3%. In-hospital, 289 patients underwent reperfusion (5.5%), 92.1% received parenteral anticoagulants; at discharge, 75.6% received direct oral anticoagulants and 6.7% vitamin K antagonists. In-hospital and 30-day mortalities were 3.4 and 4.8%, respectively. In-hospital death occurred in 20.3% high-risk patients (
conclusionFor the majority of patients with PE, contemporary initial management includes risk stratification and treatment with direct oral anticoagulants. In-hospital mortality remains high in intermediate and high-risk patients calling for and informing research focused on its reduction. TRIAL REGISTRATION NUMBER: NCT03631810.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.