ArticlePloS one2023
Mediation of the association between multi-morbidity and sleep problems by pain and depressive symptoms among older adults: Evidence from the Longitudinal Aging Study in India, wave- 1.
Article in PloS one, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed.
- Cognitive impairment among widowed older adults in India: a decomposition analysis of gender gap.BMC psychology · 2026Article
- Association between 24-h activity patterns and inhibitory control in community-dwelling older adults: a cross-sectional study based on chronic disease status.Frontiers in public health · 2026Article
- The chain mediating effects of somatic pain and depression between chronic diseases and sleep in the older patients.Sleep & breathing = Schlaf & Atmung · 2025Article
- Associations between multimorbidity burden and objective and patient-reported sleep outcomes among people with HIV.AIDS (London, England) · 2025Article
- Poor sleep quality and associated factors among community-dwelling older adult at Gondar town.Scientific reports · 2025Article
- Sleep disturbance and multimorbidity: a cross-sectional and longitudinal study in the knee pain and related health in the community cohort.Sleep advances : a journal of the Sleep Research Society · 2025Article
- Sleep duration and pain during the COVID-19 pandemic with depression and chronic diseases as mediators.Scientific reports · 2024Article
- Demographic, socioconomic, and health correlates of sleep quality and sleep duration among community-dwelling older adults in India.BMC psychiatry · 2024Article
- Moderating role of functional/ mobility limitations in the association between sleep problems and hypertension among middle-aged and older adults in India.Preventive medicine reports · 2024Article
- Association between self-perception of the neighborhood environment and sleep problems in older Brazilian adults: findings from ELSI-Brazil.Cadernos de saude publica · 2024Article
- Exploring the Causal Relationship Between Migraine and Insomnia Through Bidirectional Two-Sample Mendelian Randomization: A Bidirectional Causal Relationship.Journal of pain research · 2024Article
- Overview of multimorbidity research in India: A scoping review.Journal of multimorbidity and comorbidityReview
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3 authors.
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Abstract
backgroundThere could be several possible mechanisms on how chronic conditions relate to sleep problems in older persons; for instance, pain and sleep have a strong link and depressive symptoms are similarly associated with sleep problems. The present study explored whether pain and depressive symptoms are mediators in the relationship between multi-morbidity and sleep problems among older adults.
methodsStudy utilized data from the Longitudinal Aging Study in India (LASI) with a sample of 31,464 older adults age 60 years and above. Multivariable logistic regression along with mediation analysis using Karlson-Holm-Breen (KHB) method was conducted.
resultsA proportion of 14.8% of the participants suffered from sleep problems, whereas, 22.5% and 8.7% of older adults had multi-morbidity and had depressive symptoms, respectively. Also, around 10.3% of older adults reported pain and received no medication for the relief of pain, whereas 29.3% of older adults reported pain and received some type of medication for the relief of pain. Older adults with multi-morbidity had higher odds of suffering from sleep problems [adjusted odds ratio (aOR):1.26, confidence interval (CI):1.10-1.45] than those who had no multi-morbidity. Older adults who reported pain but received no medication for the relief of pain [aOR: 1.90, CI: 1.64-2.22] or reported pain and received medication for the relief of pain [aOR: 1.82, CI:1.62-2.04] and those who had depressive symptoms [aOR: 2.21, CI:1.89-2.57%] had higher odds of suffering from sleep problems compared to those who did not report pain and had no depressive symptoms, respectively. Around 11.2% of the association of multi-morbidity with sleep problems was mediated by pain and 4.3% of such association was mediated by depressive symptoms.
conclusionPain and depressive symptoms were found to mediate the association between multi-morbidity and sleep problems; therefore, reducing pain and depressive symptoms may be considered to improve sleep in older multi-morbid patients.
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