Evidence map›Paper›PMID 36757736›Full record

ArticleBiomacromolecules2023

Dual Thermal- and Oxidation-Responsive Polymers Synthesized by a Sequential ROP-to-RAFT Procedure Inherently Temper Neuroinflammation.

Zulfiye Y Turhan, Richard d'Arcy, Farah El Mohtadi, Lorena Infante Teixeira, Nora Francini, Mike Geven, Valentina Castagnola, Aws Alshamsan, Fabio Benfenati, Nicola Tirelli

Abstract read
In one paragraph

Article in Biomacromolecules, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zulfiye Y TurhanLaboratory for Polymers and Biomaterials, Fondazione Istituto Italiano di Tecnologia, 16163 Genova, Italy.
Richard d'ArcyLaboratory for Polymers and Biomaterials, Fondazione Istituto Italiano di Tecnologia, 16163 Genova, Italy.ORCID 0000-0002-8567-368X
Farah El MohtadiDivision of Pharmacy and Optometry, School of Health Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, United Kingdom.
Lorena Infante TeixeiraLaboratory for Polymers and Biomaterials, Fondazione Istituto Italiano di Tecnologia, 16163 Genova, Italy.
Nora FranciniLaboratory for Polymers and Biomaterials, Fondazione Istituto Italiano di Tecnologia, 16163 Genova, Italy.
Mike GevenLaboratory for Polymers and Biomaterials, Fondazione Istituto Italiano di Tecnologia, 16163 Genova, Italy.
Valentina CastagnolaCenter for Synaptic Neuroscience and Technology, Fondazione Istituto Italiano di Tecnologia, 16132 Genova, Italy.
Aws AlshamsanDepartment of Pharmaceutics, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.
Fabio BenfenatiCenter for Synaptic Neuroscience and Technology, Fondazione Istituto Italiano di Tecnologia, 16132 Genova, Italy.ORCID 0000-0002-0653-8368
Nicola TirelliLaboratory for Polymers and Biomaterials, Fondazione Istituto Italiano di Tecnologia, 16163 Genova, Italy.ORCID 0000-0002-4879-3949

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study is about multiple responsiveness in biomedical materials. This typically implies "orthogonality" (i.e., one response does not affect the other) or synergy (i.e., one increases efficacy or selectivity of the other), but an antagonist effect between responses may also occur. Here, we describe a family of very well-defined amphiphilic and micelle-forming block copolymers, which show both oxidative and temperature responses. They are produced via successive anionic ring-opening polymerization of episulfides and RAFT polymerization of dialkylacrylamides and differ only in the ratio between inert (

Indexed as

Neuroinflammatory DiseasesPolymersAnti-Inflammatory AgentsHumansMicellesPolymerizationReactive Oxygen SpeciesAnti-Inflammatory AgentsMicellesPolymersReactive Oxygen Species

Identifiers

PMID36757736
PMCPMC10565819

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.