Evidence map›Paper›PMID 36757526›Full record

ReviewJournal of neuro-oncology2023

Do animal models of brain tumors replicate human peritumoral edema? a systematic literature search.

Moritz W J Schramm, Stuart Currie, Ming-Te Lee, Laurent J Livermore, Sandeep P Solanki, Ryan K Mathew, Heiko Wurdak, Mihaela Lorger, Chris Twelves, Susan C Short and 2 more

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of neuro-oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Moritz W J SchrammSchool of Medicine, University of Leeds, Leeds, UK. moritz.schramm@doctors.org.uk.
Stuart CurrieLeeds Teaching Hospitals NHS Trust, University of Leeds, Leeds, UK.
Ming-Te LeeLeeds Teaching Hospitals NHS Trust, University of Leeds, Leeds, UK.
Laurent J LivermoreDepartment of Neurosurgery, The General Infirmary at Leeds, Great George Street, Leeds, LS1 3EX, UK.
Sandeep P SolankiUniversity Hospital Coventry & Warwickshire NHS Trust, Coventry, UK.
Ryan K MathewSchool of Medicine, University of Leeds, Leeds, UK.
Heiko WurdakSchool of Medicine, University of Leeds, Leeds, UK.
Mihaela LorgerSchool of Medicine, University of Leeds, Leeds, UK.
Chris TwelvesLeeds Teaching Hospitals NHS Trust, University of Leeds, Leeds, UK.
Susan C ShortLeeds Teaching Hospitals NHS Trust, University of Leeds, Leeds, UK.
Aruna ChakrabartyLeeds Teaching Hospitals NHS Trust, University of Leeds, Leeds, UK.
Paul ChumasDepartment of Neurosurgery, The General Infirmary at Leeds, Great George Street, Leeds, LS1 3EX, UK.
University of Leeds · GBLeeds General Infirmary · GBLeeds Teaching Hospitals NHS Trust · GBUniversity Hospital Coventry · GB

Funding

Cancer Research UK 28832
6 · The paper itself

Abstract

introductionBrain tumors cause morbidity and mortality in part through peritumoral brain edema. The current main treatment for peritumoral brain edema are corticosteroids. Due to the increased recognition of their side-effect profile, there is growing interest in finding alternatives to steroids but there is little formal study of animal models of peritumoral brain edema. This study aims to summarize the available literature.

methodsA systematic search was undertaken of 5 literature databases (Medline, Embase, CINAHL, PubMed and the Cochrane Library). The generic strategy was to search for various terms associated with "brain tumors", "brain edema" and "animal models".

resultsWe identified 603 reports, of which 112 were identified as relevant for full text analysis that studied 114 peritumoral brain edema animal models. We found significant heterogeneity in the species and strain of tumor-bearing animals, tumor implantation method and edema assessment. Most models did not produce appreciable brain edema and did not test for observable manifestations thereof.

conclusionNo animal model currently exists that enable the investigation of novel candidates for the treatment of peritumoral brain edema. With current interest in alternative treatments for peritumoral brain edema, there is an unmet need for clinically relevant animal models.

Indexed as

Brain EdemaBrain NeoplasmsAnimalsBrainEdemaHumansMagnetic Resonance ImagingAnimal modelBrain tumorEdema

Identifiers

PMID36757526
PMCPMC9992038
OpenAlexW4319656795

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.