Evidence map›Paper›PMID 36757522›Full record

ReviewInternational journal of hematology2023

Resolution of persistent SARS-CoV-2 infection with prolonged intravenous remdesivir and vaccination in a patient post CAR-T.

Sai Ambati, Bazga Ali, Owen Seddon, Andrew Godkin, Martin Scurr, Catherine Moore, Clare Rowntree, Jonathan Underwood

Abstract readCase ReportsReview
In one paragraph

Review in International journal of hematology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Observational
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sai AmbatiDepartment of Internal Medicine, Cardiff and Vale University Health Board, University Hospital of Wales, Cardiff, Wales, UK. Sai.ambati@wales.nhs.uk.ORCID http://orcid.org/0000-0002-9414-1378
Bazga AliDepartment of Infectious Disease, Cardiff and Vale University Health Board, Cardiff, Wales, UK.
Owen SeddonDepartment of Infectious Disease, Cardiff and Vale University Health Board, Cardiff, Wales, UK.
Andrew GodkinDepartment of Gastroenterology and Hepatology, Division of Infection and Immunity, School of Medicine, Cardiff and Vale University Health Board, Cardiff University, Cardiff, Wales, UK.
Martin ScurrDivision of Infection and Immunity, School of Medicine, Cardiff University, ImmunoServ Ltd, Cardiff, Wales, UK.
Catherine MooreDepartment of Virology, Cardiff and Vale University, Cardiff, Wales, UK.
Clare RowntreeDepartment of Haematology, Cardiff and Vale University Health Board, Cardiff, Wales, UK.
Jonathan UnderwoodDepartment of Infectious Disease, Division of Infection and Immunity, School of Medicine, Cardiff and Vale University Health Board, Cardiff University, Cardiff, Wales, UK.

Funding

Medical Research Council MR/T023791/1
6 · The paper itself

Abstract

SARS-CoV-2 virus is a single-stranded enveloped RNA virus, which causes coronavirus disease. Most of the immunocompetent patients with SARS-CoV-2 infection do have mild to moderate respiratory illness; however, in immunocompromised patients, the course of infection is unpredictable with high rates of infectivity and mortality. So, it is important to identify the immunocompromised patients early and establish the course of treatment accordingly. Here, we describe a 25-year-old male with background of B cell ALL, post-BMT and CAR-T therapy who received treatment with remdesivir and vaccination and was followed up for six months from the onset of symptoms to post vaccination, which showed resolution of symptoms and improvement of immunological markers. Here, we review the literature concerning the course and treatment of SARS-CoV-2 infection aimed at achieving cure in this patient.

Indexed as

COVID-19Receptors, Chimeric AntigenAdenosine MonophosphateAdultAlanineCOVID-19 Drug TreatmentHumansMaleSARS-CoV-2Adenosine MonophosphateAlanineReceptors, Chimeric AntigenremdesivirB cell ALLCAR-T therapyPost BMTRemdesivirSARS-CoV-2

Identifiers

PMID36757522
PMCPMC9909639

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.