ArticleJournal, genetic engineering & biotechnology2023
Study of exopolysaccharide produced by Streptomyces rochie strain OF1 and its effect as ameliorative on osteoarthritis in rats via inhibiting TNF-α/COX2 pathway.
Article in Journal, genetic engineering & biotechnology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 22 citations in OpenAlex.
- Bioactive metabolites from marine fungal sources: evaluation of antimicrobial and cytotoxic activities.BMC microbiology · 2026Article
- Characterization and Modeling of Marine Bacillus cereus Strain MSS1 Exopolysaccharide and Its Antagonistic Effect on Colon Cancer.Probiotics and antimicrobial proteins · 2026Article
- Revealing the therapeutic potential of bioactive exopolysaccharide (EPSS10) derived from Streptomyces sp. MAE.BMC microbiology · 2025Article
- Progress on the mechanism of natural polysaccharides in the treatment of arthritis.Inflammopharmacology · 2025Review
- A review on bacteria-derived antioxidant metabolites: their production, purification, characterization, potential applications, and limitations.Archives of pharmacal research · 2025Review
- Gold nanoparticles synthesized from soil-derivedRSC advances · 2025Article
- Isolation, Structure, and Biological Activities of Exopolysaccharides from Actinomycetes: A Review.Current microbiology · 2024Review
- Characterization and in-vitro Alzheimer's properties of exopolysaccharide from Bacillus maritimus MSM1.Scientific reports · 2023Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCarbohydrates are known as the main natural products of life activities.
resultsStreptomyces rochie strain OF1 isolated from a mangrove tree produced exopolysaccharide S5 (EPSS5) (14.2 gl
conclusionsAdministration of EPS ameliorated carrageen-induced elevation in inflammatory mediators; TNF-α/COX and suppressed the expressions of metalloproteinase 9 (MMP9) by 68%, 86%, and 75% correspondingly in comparison to the group of carrageenans. Then again, therapy involving a high dose only reduced MMP9 level by 57%, compared to free drug suggesting that EPSS5 is a good inhibitor of the MMP9, as it brought MMP9 back to normal levels via the signaling pathway.
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Registered trials
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