SynthesisDigestive diseases and sciences2023
Prognostic Factors for Non-anastomotic Biliary Strictures Following Adult Liver Transplantation: A Systematic Review and Meta-Analysis.
Synthesis in Digestive diseases and sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed.
- Rhesus Antagonism Is Associated With Non-Anastomotic Biliary Strictures After Orthotopic Liver Transplantation From Brain-Death Donors.Clinical transplantation · 2026Observational
- Case report: Complete cast formation of the entire intrahepatic biliary tree.Frontiers in medicine · 2025Article
- Endoscopic Treatment and Outcome Analysis of Biliary Stricture After Orthotopic Liver Transplantation: A Single Center Retrospective Study.International journal of general medicine · 2025Article
- Recipient warm ischemic time negatively influences biliary complications and graft survival - a single center retrospective analysis.Frontiers in gastroenterology (Lausanne, Switzerland) · 2025Article
- Prolonged warm ischemia time in the recipient is associated with post-transplant biliary stricture following living-donor liver transplantation.Surgery today · 2024Article
Corrections and comments
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Authors and funding
10 authors.
Funding
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Abstract
introductionThe development of non-anastomotic biliary strictures (NAS) following orthotopic adult liver transplantation (OLT) is associated with significant morbidity. We performed a systematic review and meta-analysis to identify all prognostic factors for the development of NAS.
methodsA systematic review was conducted following preferred reporting items for systematic reviews and meta-analyses (PRISMA) and the meta-analysis of observational studies in epidemiology (MOOSE) guidelines. We used the Newcastle-Ottawa scale to assess the quality of the included studies. Using the random-effects model, we calculated the weighted pooled odds ratios (OR), mean differences (MD), hazard ratios (HR), and 95% confidence intervals (CI) of the risk factors.
resultsBased on 19 international studies that included a total of 8269 adult LT patients, we calculated an 8% overall incidence of NAS. In this study, 7 potential prognostic factors were associated with a statistically significant hazard ratio for NAS in pooled analyses including (1) DCD donors compared to DBD donors (2) PSC as an indication for a liver transplant (3) Roux-en-Y bile duct reconstruction compared to duct-to-duct reconstruction (4) hepatic artery thrombosis (5) longer cold ischemia time (6) longer warm ischemia time (7) and total operative times.
conclusionIn this systematic review and meta-analysis, we identified 7 prognostic factors for the development of NAS following OLT. These findings might lay the groundwork for development of diagnostic algorithms to better risk stratify patients at risk for development of NAS.
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