ArticleInternational journal of geriatric psychiatry2023
Interactive association of posttraumatic stress disorder, apolipoprotein ε4 genotype, and age on cognitive functioning.
Article in International journal of geriatric psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed, 8 citations in OpenAlex.
- Improvement on Attention Networks Among Military Personnel: The Right IFG and tDCS Matter.Human brain mapping · 2025Article
- Childhood Trauma andmedRxiv : the preprint server for health sciences · 2025Article
- Posttraumatic Stress Disorder Symptoms and Cardiovascular and Brain Health in Women.JAMA network open · 2023Article
Corrections and comments
- Erratum issuedCorrigendum.2023
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundThe ε4 allele of the apolipoprotein (APOE) gene and posttraumatic stress disorder (PTSD) are associated with cognitive deficits. Both associations may vary depending on age. No previous study has examined a possible three-way interaction between APOE ε4, PTSD, and age on cognitive functioning.
methodsData were analyzed from 1244 European-American U.S. military veterans who participated in the 2011 National Health and Resilience in Veterans Study (NHRVS). Analyses of covariance were used to examine the main effects and interactions of APOE ε4, PTSD, and age on learning/working memory (LWM) and attention/psychomotor (APM) performance.
resultsA significant three-way interaction between APOE ε4, PTSD, and age on the LWM composite (η
conclusionOlder APOE ε4 carriers with probable PTSD showed poorer LWM performance relative to other groups. Aging-related associations on APM performance were most pronounced in veterans with PTSD. These data are preliminary evidence that identification and treatment of PTSD may be beneficial for individuals at risk for age-related cognitive impairment.
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