Evidence map›Paper›PMID 36756808›Full record

ArticlePaediatric and perinatal epidemiology2023

The Pregnancy, Arsenic, and Immune Response (PAIR) Study in rural northern Bangladesh.

Lindsay N Avolio, Tyler J S Smith, Ana Navas-Acien, Kate Kruczynski, Nora Pisanic, Pranay R Randad, Barbara Detrick, Rebecca C Fry, Alexander van Geen, Walter Goessler and 21 more

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Paediatric and perinatal epidemiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03930017 (Arsenic and Immune Response to Influenza Vaccination in Pregnant Women and Newborns), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03930017 completednot on this map

Arsenic and Immune Response to Influenza Vaccination in Pregnant Women and Newborns

TypeobservationalSponsorJohns Hopkins Bloomberg School of Public HealthRan2018 to 2020Enrolled784ConditionsArsenic--Toxicology, Immunologic Disorders Complicating Pregnancy, Vaccine Response Impaired, Micronutrient DeficiencyArmsSeasonal influenza vaccine - VAXIGRIP TETRA influenza vaccine (quadrivalent, split virion, inactivated)
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors at 8 institutions in 3 countries.

Lindsay N AvolioDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.ORCID 0000-0002-5484-567X
Tyler J S SmithDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.ORCID 0000-0003-4692-2206
Ana Navas-AcienDepartment of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, New York, USA.ORCID 0000-0001-9824-7797
Kate KruczynskiDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.ORCID 0000-0002-2702-6265
Nora PisanicDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.ORCID 0000-0002-0042-9232
Pranay R RandadDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Barbara DetrickDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-3776-4210
Rebecca C FryDepartment of Environmental Sciences and Engineering, University of North Carolina at Chapel Hill Gillings School of Global Public Health, Chapel Hill, North Carolina, USA.ORCID 0000-0003-0899-9018
Alexander van GeenLamont-Doherty Earth Observatory, Columbia University, Palisades, New York, USA.ORCID 0000-0003-2073-9841
Walter GoesslerInstitute of Chemistry - Analytical Chemistry, University of Graz, Graz, Austria.
Ruth A KarronDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Sabra L KleinDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.ORCID 0000-0002-0730-5224
Elizabeth L OgburnDepartment of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.ORCID 0000-0001-7036-7973
Marsha Wills-KarpDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.ORCID 0000-0001-7929-1362
Kelsey AllandDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.ORCID 0000-0001-8464-6308
Kaniz AyeshaJiVitA Maternal and Child Health and Nutrition Research Project, Gaibandha, Bangladesh.
Brian DyerDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.ORCID 0000-0001-9178-1807
Md Tanvir IslamJiVitA Maternal and Child Health and Nutrition Research Project, Gaibandha, Bangladesh.ORCID 0000-0003-0813-1323
Habibat A OguntadeDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Md Hafizur RahmanJiVitA Maternal and Child Health and Nutrition Research Project, Gaibandha, Bangladesh.
Hasmot AliJiVitA Maternal and Child Health and Nutrition Research Project, Gaibandha, Bangladesh.ORCID 0000-0003-0044-1992
Rezwanul HaqueJiVitA Maternal and Child Health and Nutrition Research Project, Gaibandha, Bangladesh.
Saijuddin ShaikhJiVitA Maternal and Child Health and Nutrition Research Project, Gaibandha, Bangladesh.
Kerry J SchulzeDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
A K M MuraduzzamanInstitute of Epidemiology, Disease Control, and Research, Dhaka, Bangladesh.
A S M AlamgirInstitute of Epidemiology, Disease Control, and Research, Dhaka, Bangladesh.
Meerjady S FloraInstitute of Epidemiology, Disease Control, and Research, Dhaka, Bangladesh.ORCID 0000-0001-5172-1295
Keith P WestDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.ORCID 0000-0001-9458-362X
Alain B LabriqueDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.ORCID 0000-0003-2502-7819
Christopher D HeaneyDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.ORCID 0000-0003-3211-8495
JiVitA Maternal and Child Health and Nutrition Research Project
Johns Hopkins University · USChild Health Research Foundation · BDInstitute of Epidemiology, Disease Control and Research · BDColumbia University · USLamont-Doherty Earth Observatory · USUniversity of Graz · ATUniversity of Minnesota · USUniversity of North Carolina at Chapel Hill · US

Funding

True Metal fac coreP30ES009089 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MATTHEW S PERZANOWSKI · 1998 to 2026
$44.7M
UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel · 2001 to 2026
$36.3M
Traning Program in Environmental Health SciencesT32ES007141 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI Marsha Wills-Karp · 1985 to 2026
$22.2M
Research Experience and Training Coordination CoreP42ES033719 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Ana Navas-Acien · 2022 to 2026
$11.9M
Arsenic and immune response to influenza vaccination in pregnant women and newbornsR01ES026973 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI HEANEY, CHRISTOPHER D, LABRIQUE, ALAIN BERNARD · 2017 to 2021
$3.6M
NIEHS NIH HHS P30 ES009089NIEHS NIH HHS P30 ES010126NIEHS NIH HHS P42 ES033719NIEHS NIH HHS R01 ES026973NIEHS NIH HHS T32 ES007141NIOSH CDC HHS T42 OH008428
6 · The paper itself

Abstract

backgroundArsenic exposure and micronutrient deficiencies may alter immune reactivity to influenza vaccination in pregnant women, transplacental transfer of maternal antibodies to the foetus, and maternal and infant acute morbidity.

objectivesThe Pregnancy, Arsenic, and Immune Response (PAIR) Study was designed to assess whether arsenic exposure and micronutrient deficiencies alter maternal and newborn immunity and acute morbidity following maternal seasonal influenza vaccination during pregnancy. POPULATION: The PAIR Study recruited pregnant women across a large rural study area in Gaibandha District, northern Bangladesh, 2018-2019.

designProspective, longitudinal pregnancy and birth cohort.

methodsWe conducted home visits to enrol pregnant women in the late first or early second trimester (11-17 weeks of gestational age). Women received a quadrivalent seasonal inactivated influenza vaccine at enrolment. Follow-up included up to 13 visits between enrolment and 3 months postpartum. Arsenic was measured in drinking water and maternal urine. Micronutrient deficiencies were assessed using plasma biomarkers. Vaccine-specific antibody titres were measured in maternal and infant serum. Weekly telephone surveillance ascertained acute morbidity symptoms in women and infants. PRELIMINARY

resultsWe enrolled 784 pregnant women between October 2018 and March 2019. Of 784 women who enrolled, 736 (93.9%) delivered live births and 551 (70.3%) completed follow-up visits to 3 months postpartum. Arsenic was detected (≥0.02 μg/L) in 99.7% of water specimens collected from participants at enrolment. The medians (interquartile ranges) of water and urinary arsenic at enrolment were 5.1 (0.5, 25.1) μg/L and 33.1 (19.6, 56.5) μg/L, respectively. Water and urinary arsenic were strongly correlated (Spearman's ⍴ = 0.72) among women with water arsenic ≥ median but weakly correlated (⍴ = 0.17) among women with water arsenic < median.

conclusionsThe PAIR Study is well positioned to examine the effects of low-moderate arsenic exposure and micronutrient deficiencies on immune outcomes in women and infants. REGISTRATION: NCT03930017.

Indexed as

ArsenicInfluenza, HumanBangladeshFemaleHumansImmunityInfantInfant, NewbornMicronutrientsPregnancyProspective StudiesWaterArsenicMicronutrientsWaterarsenicimmunogenicityinfluenzamicronutrientspregnancyprenatal exposure delayed effectsvaccines

Identifiers

PMID36756808
PMCPMC10096093
OpenAlexW4319655579

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.