Evidence map›Paper›PMID 36756776›Full record

ReviewMolecules and cells2023

The Role of Pyruvate Metabolism in Mitochondrial Quality Control and Inflammation.

Min-Ji Kim, Hoyul Lee, Dipanjan Chanda, Themis Thoudam, Hyeon-Ji Kang, Robert A Harris, In-Kyu Lee

Open access · diamondAbstract readReview
In one paragraph

Review in Molecules and cells, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 1 pooled it
11.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 1 synthesis or guideline pooled it, 73 citations in OpenAlex.

  1. Pooled it
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  8. [Ursolic acid inNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2026
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  12. Cancer cachexia: molecular basis and therapeutic advances.Signal transduction and targeted therapy · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Min-Ji KimDepartment of Internal Medicine, School of Medicine, Kyungpook National University Chilgok Hospital, Daegu 41404, Korea.ORCID https://orcid.org/0000-0003-4303-502X
Hoyul LeeResearch Institute of Aging and Metabolism, Kyungpook National University, Daegu 41566, Korea.ORCID https://orcid.org/0000-0002-1655-0985
Dipanjan ChandaResearch Institute of Aging and Metabolism, Kyungpook National University, Daegu 41566, Korea.ORCID https://orcid.org/0000-0003-0685-187X
Themis ThoudamResearch Institute of Aging and Metabolism, Kyungpook National University, Daegu 41566, Korea.ORCID https://orcid.org/0000-0002-3845-2964
Hyeon-Ji KangResearch Institute of Aging and Metabolism, Kyungpook National University, Daegu 41566, Korea.ORCID https://orcid.org/0000-0003-4481-2708
Robert A HarrisDepartment of Biochemistry and Molecular Biology, The University of Kansas Medical Center, Kansas City, KS 66160, USA.ORCID https://orcid.org/0000-0003-3108-4748
In-Kyu LeeDepartment of Internal Medicine, Kyungpook National University Hospital, School of Medicine, Kyungpook National University, Daegu 41944, Korea.ORCID https://orcid.org/0000-0002-2261-7269
Kyungpook National University · KRKyungpook National University Hospital · KRUniversity of Kansas Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pyruvate metabolism, a key pathway in glycolysis and oxidative phosphorylation, is crucial for energy homeostasis and mitochondrial quality control (MQC), including fusion/fission dynamics and mitophagy. Alterations in pyruvate flux and MQC are associated with reactive oxygen species accumulation and Ca

Indexed as

Insulin ResistanceHumansInflammationMitochondriaPyruvate Dehydrogenase Acetyl-Transferring KinasePyruvatesPyruvate Dehydrogenase Acetyl-Transferring KinasePyruvatesmacrophagemitochondria-associated membranesmitochondria quality controlpyruvate dehydrogenase complexpyruvate dehydrogenase kinaseT cell

Identifiers

PMID36756776
PMCPMC10183795
OpenAlexW4319656282

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.