ArticleRSC advances2023
Cytotoxicity profiling of choline chloride-based natural deep eutectic solvents.
Article in RSC advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 77 citations in OpenAlex.
- Drug-delivery oriented solubility enhancement of curcumin in choline chloride-based acidic deep eutectic solvents: thermodynamic analysis and MCF-7 cytotoxicity assessment.BMC chemistry · 2026Article
- Plant Monoterpenes Geraniol, Eugenol and Carvacrol Against Multidrug-Resistant ESKAPE Isolates from Surgical Wounds.Antibiotics (Basel, Switzerland) · 2026Article
- Beyond Composition: Structure-Activity Relationships in Bioactive Deep Eutectic Systems.Pharmaceutics · 2026Review
- Ultrasound-assisted deep eutectic solvent extraction of polysaccharides from Melastoma dodecandrum: RSM optimization, ANN prediction, kinetics, structural characterization and cellular antioxidant activity.Ultrasonics sonochemistry · 2026Article
- NMR Spectroscopy: Molecular Insights into Cell Wall Collapse and Oxidative Stress ofACS omega · 2026Article
- Molecular interactions, solubility, and cytotoxic activity of 4‑hydroxycoumarin in choline chloride‑based acidic deep eutectic solvents.Scientific reports · 2026Article
- Sustainable valorization of grape pomace peels using NADES: a focus on selective recovery of anthocyanins and flavonols and bioactivity.Analytical and bioanalytical chemistry · 2026Article
- A Microfiber-Reinforced Janus Hydrogel E-Skin With Recyclable Feature for Multimodal Sensing and Gender-Specific Physiological Monitoring.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Tailorable Antibacterial Activity and Biofilm Eradication Properties of Biocompatible α-Hydroxy Acid-Based Deep Eutectic Solvents.Pharmaceutics · 2025Article
- Safety of NADES Extract ofMolecules (Basel, Switzerland) · 2025Article
- Influence of Natural Deep Eutectic Solvent Compositions on the Polyphenol Profile ofMolecules (Basel, Switzerland) · 2025Article
- Extraction and Identification of Active Components fromMolecules (Basel, Switzerland) · 2025Article
- Doping of PDMS-NQS Sensors to Modify Their Response and Sustainability: Ammonia Quantitation in Farm Atmospheres as a Case Study.Polymers · 2025Article
- Exploitation of ApulianMolecules (Basel, Switzerland) · 2025Article
- An Overview on the Role of Ionic Liquids and Deep Eutectic Solvents in Oral Pharmaceuticals.Pharmaceutics · 2025Review
- Synthesis of Thiazolo[5,4-Molecules (Basel, Switzerland) · 2025Article
- Environmental Implications of Ionic Liquid and Deep Eutectic Solvent in Geothermal Application: Comparing Traditional and New Approach Methods.ACS sustainable chemistry & engineering · 2024Article
- Antibacterial and antifungal activities of natural deep eutectic solvents.Applied microbiology and biotechnology · 2024Review
- Caco-2 Cell Line Standardization with Pharmaceutical Requirements and In Vitro Model Suitability for Permeability Assays.Pharmaceutics · 2023Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aims to examine in detail for the first time the cytotoxic profile of twelve choline chloride-based deep eutectic solvents (NADES) against HT-29, Caco-2, MCF-7, and MRC-5 cell lines. All NADES systems were synthesized by microwave synthesis using choline chloride as a hydrogen bond acceptor (HBA) and selected sugars, alcohols, organic acids, and urea as hydrogen bond donors (HBD) with the addition of 20% water (w/w) to all systems. It was observed that the cytotoxic effect predominantly depended on the structure of HBD. Acidic systems, where HBDs were organic acids showed the highest cytotoxic effects in all investigated cell lines. The cytotoxicity depended mostly on the concentration of the NADES system in the cell medium as well as on the chemical constitution of the investigated systems. The highest cytotoxic effects showed acidic systems, especially to the HT-29 cell line. The EC
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.