Evidence map›Paper›PMID 36756348›Full record

ArticleFrontiers in neurology2022

Association between fatigue and cytokine profiles in patients with ischemic stroke.

Inge Kirchberger, Christa Meisinger, Dennis Freuer, Vincenza Leone, Michael Ertl, Philipp Zickler, Markus Naumann, Jakob Linseisen

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Neuroimmune Mechanisms and Emerging Intervention Strategies for Post-Stroke Fatigue: A Narrative Review.Medical science monitor : international medical journal of experimental and clinical research · 2026
    Review
  3. Article
  4. Are central and systemic inflammation associated with fatigue in cerebral small vessel disease?International journal of stroke : official journal of the International Stroke Society · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Inge KirchbergerEpidemiology, Faculty of Medicine, University of Augsburg, Augsburg, Germany.
Christa MeisingerEpidemiology, Faculty of Medicine, University of Augsburg, Augsburg, Germany.
Dennis FreuerEpidemiology, Faculty of Medicine, University of Augsburg, Augsburg, Germany.
Vincenza LeoneEpidemiology, Faculty of Medicine, University of Augsburg, Augsburg, Germany.
Michael ErtlDepartment of Neurology and Clinical Neurophysiology, University Hospital Augsburg, Augsburg, Germany.
Philipp ZicklerDepartment of Neurology and Clinical Neurophysiology, University Hospital Augsburg, Augsburg, Germany.
Markus NaumannDepartment of Neurology and Clinical Neurophysiology, University Hospital Augsburg, Augsburg, Germany.
Jakob LinseisenEpidemiology, Faculty of Medicine, University of Augsburg, Augsburg, Germany.
University Hospital Augsburg · DEUniversity of Augsburg · DELudwig-Maximilians-Universität München · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Chronic fatigue is a common symptom after a stroke. Studies suggested that chronic fatigue is caused by inflammatory or immunological processes but data are limited and contradictory. Thus, the present study aimed to identify specific biomarkers associated with fatigue in post-stroke patients and replicated the findings in a population-based study. Methods: We investigated associations between 39 circulating biomarkers of inflammation and fatigue in 327 patients after an ischemic stroke included in the Stroke Cohort Augsburg (SCHANA) study and the "Metabolism, Nutrition and Immune System in Augsburg" (MEIA) study ( Results: In patients with stroke, SCGFb was inversely associated [-1.67, 95% confidence interval (CI) (-3.05; -0.29) Conclusion: The present findings suggested an association between the growth factor SCF and fatigue. Future research on cytokines as possible markers of fatigue should focus on a longitudinal design including a sufficiently large number of study participants to enable testing associations between certain cytokines and sub-groups of chronic fatigue.

Indexed as

biomarkerscytokinefatigueinflammationstroke

Identifiers

PMID36756348
PMCPMC9899860
OpenAlexW4317718144

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.