Evidence map›Paper›PMID 36756280›Full record

ArticleNeuroscience insights2023

SARS-CoV-2 and Hypertension: Evidence Supporting Invasion into the Brain Via Baroreflex Circuitry and the Role of Imbalanced Renin-Angiotensin-Aldosterone-System.

Kellysson Bruno Oliveira, Igor Santana de Melo, Bianca Rodrigues Melo da Silva, Keylla Lavínia da Silva Oliveira, Robinson Sabino-Silva, Lucas Anhezini, Pedro Lourenco Katayama, Victor Rodrigues Santos, Ashok K Shetty, Olagide Wagner de Castro

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience insights, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Cardiac Baroreflex Is Preserved After the Recovery From COVID-19 Men and Women.Journal of clinical hypertension (Greenwich, Conn.) · 2025
    Article
  3. Risk of Arterial Hypertension After COVID-19 Recovery.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Kellysson Bruno OliveiraDepartment of Physiology, Institute of Biological Sciences and Health, Federal University of Alagoas (UFAL), Maceió, Alagoas, Brazil.
Igor Santana de MeloDepartment of Physiology, Institute of Biological Sciences and Health, Federal University of Alagoas (UFAL), Maceió, Alagoas, Brazil.
Bianca Rodrigues Melo da SilvaDepartment of Physiology, Institute of Biological Sciences and Health, Federal University of Alagoas (UFAL), Maceió, Alagoas, Brazil.
Keylla Lavínia da Silva OliveiraDepartment of Physiology, Institute of Biological Sciences and Health, Federal University of Alagoas (UFAL), Maceió, Alagoas, Brazil.
Robinson Sabino-SilvaDepartment of Physiology, Institute of Biomedical Sciences, Federal University of Uberlandia (UFU), Uberlândia, Minas Gerais, Brazil.
Lucas AnheziniDepartment of Histology, Institute of Biological Sciences and Health, Federal University of Alagoas, Maceió, Alagoas, Brazil.
Pedro Lourenco KatayamaDepartment of Physiology and Pathology, Dentistry School of Araraquara, São Paulo State University, Araraquara, São Paulo, Brazil.
Victor Rodrigues SantosDepartment of Morphology, Institute of Biological Science, Federal University of Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil.
Ashok K ShettyInstitute for Regenerative Medicine, Department of Cell Biology and Genetics, Texas A&M University School of Medicine, College Station, TX, USA.ORCID https://orcid.org/0000-0001-5049-6671
Olagide Wagner de CastroDepartment of Physiology, Institute of Biological Sciences and Health, Federal University of Alagoas (UFAL), Maceió, Alagoas, Brazil.ORCID https://orcid.org/0000-0002-1874-509X
Universidade Federal de Alagoas · BRCentro Universitário de Araraquara · BRTexas A&M University · USUniversidade Federal de Minas Gerais · BRUniversidade Federal de Uberlândia · BR

Funding

Mesenchymal Stem Cell Derived Extracellular Vesicles for Traumatic Brain InjuryR01NS106907 · NINDS · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI ASHOK K SHETTY · 2018 to 2026
$4.0M
NINDS NIH HHS R01 NS106907
6 · The paper itself

Abstract

Hypertension is considered one of the most critical risk factors for COVID-19. Evidence suggests that SARS-CoV-2 infection produces intense effects on the cardiovascular system by weakening the wall of large vessels via vasa-vasorum. In this commentary, we propose that SARS-CoV-2 invades carotid and aortic baroreceptors, leading to infection of the

Indexed as

angiotensin IIbaroreflexhypertensionSARS-CoV-2

Identifiers

PMID36756280
PMCPMC9900164
OpenAlexW4318763293

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.