Evidence map›Paper›PMID 36756210›Full record

ArticleMaterials today. Bio2023

Unlocking the magic in mycelium: Using synthetic biology to optimize filamentous fungi for biomanufacturing and sustainability.

Charles Jo, Jing Zhang, Jenny M Tam, George M Church, Ahmad S Khalil, Daniel Segrè, Tzu-Chieh Tang

Abstract read
In one paragraph

Article in Materials today. Bio, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Bio-guided discovery of antibacterial metabolites fromJournal of enzyme inhibition and medicinal chemistry · 2025
    Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Journal of the Royal Society, Interface · 2025
    Article
  12. Review
  13. Review
  14. Review
  15. Review
  16. Review
  17. Whole genome sequence ofFrontiers in microbiology · 2025
    Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Charles JoDepartment of Biomedical Engineering, Boston University, Boston, MA, USA.
Jing ZhangBiological Design Center, Boston University, Boston, MA, USA.
Jenny M TamDepartment of Genetics, Harvard Medical School, Boston, MA, USA.
George M ChurchDepartment of Genetics, Harvard Medical School, Boston, MA, USA.
Ahmad S KhalilDepartment of Biomedical Engineering, Boston University, Boston, MA, USA.
Daniel SegrèDepartment of Biomedical Engineering, Boston University, Boston, MA, USA.
Tzu-Chieh TangDepartment of Genetics, Harvard Medical School, Boston, MA, USA.

Funding

Programmable benchtop bioreactors for scalable eco-evolutionary dynamics of the human microbiomeR01AI171100 · NIAID · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI KHALIL, AHMAD SAMIR, RAKOFF-NAHOUM, SETH · 2022 to 2025
$4.1M
Synthetic Biology and Biotechnology (SB2) Predoctoral Training ProgramT32GM130546 · NIGMS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI CHEN, CHRISTOPHER S, KHALIL, AHMAD SAMIR · 2019 to 2023
$1.0M
NIAID NIH HHS R01 AI171100NIGMS NIH HHS T32 GM130546
6 · The paper itself

Abstract

Filamentous fungi drive carbon and nutrient cycling across our global ecosystems, through its interactions with growing and decaying flora and their constituent microbiomes. The remarkable metabolic diversity, secretion ability, and fiber-like mycelial structure that have evolved in filamentous fungi have been increasingly exploited in commercial operations. The industrial potential of mycelial fermentation ranges from the discovery and bioproduction of enzymes and bioactive compounds, the decarbonization of food and material production, to environmental remediation and enhanced agricultural production. Despite its fundamental impact in ecology and biotechnology, molds and mushrooms have not, to-date, significantly intersected with synthetic biology in ways comparable to other industrial cell factories (e.g.

Indexed as

BiomanufacturingFilamentous fungiMaterialsStrain optimizationSustainabilitySynthetic biology

Identifiers

PMID36756210
PMCPMC9900623

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.