Evidence map›Paper›PMID 36755921›Full record

ArticleFrontiers in endocrinology2023

Zebrafish Tric-b is required for skeletal development and bone cells differentiation.

Francesca Tonelli, Laura Leoni, Valentina Daponte, Roberta Gioia, Silvia Cotti, Imke A K Fiedler, Daria Larianova, Andy Willaert, Paul J Coucke, Simona Villani and 5 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in endocrinology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
5.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. CaMKII inhibition due to TRIC-B loss-of-function dysregulates SMAD signaling in osteogenesis imperfecta.Matrix biology : journal of the International Society for Matrix Biology · 2023
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 3 countries.

Francesca TonelliDepartment of Molecular Medicine, Biochemistry Unit, University of Pavia, Pavia, Italy.
Laura LeoniDepartment of Molecular Medicine, Biochemistry Unit, University of Pavia, Pavia, Italy.
Valentina DaponteDepartment of Molecular Medicine, Biochemistry Unit, University of Pavia, Pavia, Italy.
Roberta GioiaDepartment of Molecular Medicine, Biochemistry Unit, University of Pavia, Pavia, Italy.
Silvia CottiDepartment of Biology, Ghent University, Ghent, Belgium.
Imke A K FiedlerDepartment of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Daria LarianovaDepartment of Biology, Ghent University, Ghent, Belgium.
Andy WillaertDepartment of Biomolecular Medicine, Center of Medical Genetics, Ghent University-University Hospital, Ghent, Belgium.
Paul J CouckeDepartment of Biomolecular Medicine, Center of Medical Genetics, Ghent University-University Hospital, Ghent, Belgium.
Simona VillaniDepartment of Public Health and Experimental and Forensic Medicine, Unit of Biostatistics and Clinical Epidemiology, University of Pavia, Pavia, Italy.
Björn BusseDepartment of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Roberta BesioDepartment of Molecular Medicine, Biochemistry Unit, University of Pavia, Pavia, Italy.
Antonio RossiDepartment of Molecular Medicine, Biochemistry Unit, University of Pavia, Pavia, Italy.
P Eckhard WittenDepartment of Biology, Ghent University, Ghent, Belgium.
Antonella ForlinoDepartment of Molecular Medicine, Biochemistry Unit, University of Pavia, Pavia, Italy.
University of Pavia · ITGhent University · BEGhent University Hospital · BEUniversität Hamburg · DEUniversity Medical Center Hamburg-Eppendorf · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Trimeric intracellular potassium channels TRIC-A and -B are endoplasmic reticulum (ER) integral membrane proteins, involved in the regulation of calcium release mediated by ryanodine (RyRs) and inositol 1,4,5-trisphosphate (IP Results: In this study, we exploited zebrafish to elucidate the role of TRIC-B in skeletal tissue. We demonstrated, for the first time, that Discussion: Our data support the requirement of Tric-b during early development and for bone cell differentiation.

Indexed as

Ion ChannelsOsteogenesis ImperfectaZebrafishZebrafish ProteinsAnimalsBone and BonesCalciumCell DifferentiationCalciumIon ChannelsZebrafish Proteinsbonecollagenendoplasmic reticulumfin regenerationosteogenesis imperfectaTRIC-Bzebrafish

Identifiers

PMID36755921
PMCPMC9899828
OpenAlexW4317717864

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.