ArticleClinical ophthalmology (Auckland, N.Z.)2023
Association of Triglyceride Glucose Index with Prevalence and Incidence of Diabetic Retinopathy in a Singaporean Population.
Article in Clinical ophthalmology (Auckland, N.Z.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 18 citations in OpenAlex.
- The triglyceride-glucose index as a biomarker of diabetic retinopathy: a systematic review and meta-analysis.Frontiers in medicine · 2025Pooled it
- Association between the triglyceride glucose index and diabetic retinopathy in type 2 diabetes: a meta-analysis.Frontiers in endocrinology · 2023Pooled it
- Baseline microperimetry and metabolic status predict functional outcomes in diabetic macular oedema: a prospective cohort study of anti-VEGF therapy.Annals of medicine · 2026Article
- Triglyceride-Glucose-Related Indexes as Risk Factors for Vision-Threatening Ocular Diseases: A Prospective UK Biobank Study.Investigative ophthalmology & visual science · 2026Article
- Article
- Triglyceride-Glucose Indexes Are Predictive of Early and Severe Diabetic Retinal Microvascular Abnormalities: A Prospective Cohort Study.Ophthalmology science · 2026Article
- Triglyceride-glucose index, genetic susceptibility, and trajectory of microvascular multimorbidity in type 2 diabetes.Scientific reports · 2026Article
- Association between triglyceride-glucose index and diabetic retinopathy among patients with diabetes mellitus in Nepalese patients: a cross-sectional study.BMC endocrine disorders · 2026Observational
- Article
- Predictive value of triglyceride-glucose index and sex hormone-binding globulin in diabetic retinopathy.International journal of ophthalmology · 2026Article
- Predictive value of the Triglyceride-Glucose index in diabetic macular edema: A comparative analysis with HbA1c.Journal of diabetes and metabolic disorders · 2025Article
- Elevated Triglyceride-Glucose Index as a Risk Stratification Marker for Diabetic Retinopathy in Type 2 Diabetes Mellitus: The Influence of Glycemic Control.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- Association between triglyceride-glucose index and cataract among outpatient US adults.Frontiers in medicine · 2025Article
- Role of Triglyceride-Glucose Index in Type 2 Diabetes Mellitus and Its Complications.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Review
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To examine the association of triglyceride glucose (TyG) index (product of fasting triglyceride and glucose) with prevalence and incidence of diabetic retinopathy (DR) in type 2 diabetes. Methods: 1339 patients from an ongoing Singapore Study of Macro-angiopathy and Micro-Vascular Reactivity in Type 2 Diabetes (SMART2D) were included in this study. Fasting triglyceride and glucose levels were quantified and color fundus photographs were assessed for DR presence and severity. Logistic regression models were used to evaluate associations of TyG index with DR prevalence and incidence (median follow-up period = 3.2 years). Results: Mean TyG index was higher in patients with DR than no DR (9.24±0.7 versus 9.04± 0.6, p<0.001). TyG index was significantly associated with DR prevalence (OR=1.4, CI 1.1-1.7, p=0.002) and incidence (OR=1.8, CI 1.04-2.9, p=0.03), after adjusting for confounders. In a stratified analysis, the association between TyG index and DR prevalence reached significance only in the subgroup with HbA1c levels < 7.0% (OR=2, CI 1.1-3.8, p=0.03). TyG index significantly predicted DR prevalence and incidence with area under receiver operating curve as 0.77 (CI 0.74-0.80, p <0.001) and 0.66 (CI 0.57-0.76, p value <0.01), respectively. Conclusion: TyG index is a good predictor for DR prevalence and incidence. It can also be a secondary treatment target for patients with optimally controlled levels of HbA1c.
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