ArticleHeliyon2023
Damp-heat constitution influences gut microbiota and urine metabolism of Chinese infants.
Article in Heliyon, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 9 citations in OpenAlex.
- Metabolic insights into metabolic dysfunction-associated steatotic liver disease: the impact of gut microbiota and TCM constitutions.Archives of medical science : AMS · 2026Article
- Gut microbiome and urinary metabolomic alterations in Chinese infants with functional constipation and yin-deficiency constitution.Frontiers in microbiology · 2026Article
- Dysbiosis of gut microbiota in children with functional constipation and damp-heat constitution: a cross-sectional multi-omics analysis.Scientific reports · 2025Article
- Article
- Sound as a bell: a deep learning approach for health status classification through speech acoustic biomarkers.Chinese medicine · 2024Article
- The increased tendency for anemia in traditional Chinese medicine deficient body constitution is associated with the gut microbiome.Frontiers in nutrition · 2024Article
- Gut microbial composition associated with risk of premature aging in women with Yin-deficiency constitution.Frontiers in cellular and infection microbiology · 2024Article
- Alterations in gut microbiota and urine metabolomics in infants with yin-deficiency constitution aged 0-2 years.Heliyon · 2023Article
- Application of machine learning models in predicting insomnia severity: an integrative approach with constitution of traditional Chinese medicine.Frontiers in medicine · 2023Article
- Impact of Different Traditional Chinese Medicine Constitutions on the Clinical Outcomes of COVID-19 Patients Infected with SARS-CoV-2 Omicron Variant: A Retrospective Observational Study.Infection and drug resistance · 2023Article
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: As an increasingly popular complementary and alternative approach for early detection and treatment of disease, traditional Chinese medicine constitution (TCMC) divides human beings into those with balanced constitution (BC) and unbalanced constitution, where damp-heat constitution (DHC) is one of the most unbalanced constitutions. Many studies have been carried out on the microscopic mechanism of constitution classification; however, most of these studies were conducted in adults and rarely in infants. Many diseases are closely related to intestinal microbiota, and metabolites produced by the interaction between microbiota and the body may impact constitution classification. Herein, we investigated the overall constitution distribution in Chinese infants, and analyzed the profiles of gut microbiota and urine metabolites of DHC to further promote the understanding of infants constitution classification. Methods: General information was collected and TCMC was evaluated by Constitutional Medicine Questionnaires. 1315 questionnaires were received in a cross-sectional study to investigate the constitution composition in Chinese infants. A total of 56 infants, including 30 DHC and 26 BC, were randomly selected to analyze gut microbiota by 16S rRNA sequencing and urine metabolites by UPLC-Q-TOF/MS method. Results: BC was the most common constitution in Chinese infants, DHC was the second common constitution. The gut microbiota and urine metabolites in the DHC group showed different composition compared to the BC group. Four differential genera and twenty differential metabolites were identified. In addition, the combined marker composed of four metabolites may have the high potential to discriminate DHC from BC with an AUC of 0.765. Conclusions: The study revealed the systematic differences in the gut microbiota and urine metabolites between infants with DHC and BC. Moreover, the differential microbiota and metabolites may offer objective evidences for constitution classification.
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