Evidence map›Paper›PMID 36755585›Full record

ArticleHeliyon2023

Homocysteine-induced endoplasmic reticulum stress activates FGF21 and is associated with browning and atrophy of white adipose tissue in

Manya Warrier, Evan M Paules, Jorge Silva-Gomez, Walter B Friday, Frances Bramlett, Hyunbae Kim, Kezhong Zhang, Isis Trujillo-Gonzalez

Open access · goldAbstract read
In one paragraph

Article in Heliyon, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
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  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Manya WarrierDepartment of Nutrition, UNC Nutrition Research Institute, UNC-Chapel Hill, Kannapolis, NC, USA.
Evan M PaulesDepartment of Nutrition, UNC Nutrition Research Institute, UNC-Chapel Hill, Kannapolis, NC, USA.
Jorge Silva-GomezDepartment of Nutrition, UNC Nutrition Research Institute, UNC-Chapel Hill, Kannapolis, NC, USA.
Walter B FridayDepartment of Nutrition, UNC Nutrition Research Institute, UNC-Chapel Hill, Kannapolis, NC, USA.
Frances BramlettDepartment of Nutrition, UNC Nutrition Research Institute, UNC-Chapel Hill, Kannapolis, NC, USA.
Hyunbae KimCenter for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI, USA.
Kezhong ZhangCenter for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI, USA.
Isis Trujillo-GonzalezDepartment of Nutrition, UNC Nutrition Research Institute, UNC-Chapel Hill, Kannapolis, NC, USA.
University of North Carolina Health Care · USUniversity of North Carolina at Chapel Hill · USWayne State University · US

Funding

UNIV OF NORTH CAROLINA CLINICAL NUTRITION RESEARCH UNITP30DK056350 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Venkata Saroja Voruganti · 1999 to 2026
$31.6M
Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DAVID P OLSON · 2013 to 2026
$24.3M
Regulation of Hepatic Steatosis by an ER Stress-Inducible Transcription Factor CRR01DK090313 · NIDDK · WAYNE STATE UNIVERSITY · PI Kezhong Zhang · 2011 to 2026
$5.0M
Nutrigenetic analysis of choline status biomarkersR01DK115380 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ZEISEL, STEVEN H · 2018 to 2021
$2.8M
Regulation of Rhythmic m6A RNA Modification by ER‐associated DegradationR01DK126908 · NIDDK · WAYNE STATE UNIVERSITY · PI FANG, DEYU, ZHANG, KEZHONG · 2021 to 2024
$2.2M
Mitochondrial NAD kinase: function and mechanism in metabolismR01DK132065 · NIDDK · WAYNE STATE UNIVERSITY · PI ZHANG, KEZHONG, ZHANG, REN · 2022 to 2025
$1.5M
NIDDK NIH HHS P30 DK020572NIDDK NIH HHS P30 DK056350NIDDK NIH HHS R01 DK090313NIDDK NIH HHS R01 DK115380NIDDK NIH HHS R01 DK126908
6 · The paper itself

Abstract

Betaine-homocysteine methyltransferase (BHMT) catalyzes the transfer of methyl groups from betaine to homocysteine (Hcy), producing methionine and dimethylglycine. In this work, we characterize

Indexed as

Betaine-homocysteine S-MethyltransferaseBHMTCREBHER stressFGF21HomocysteineLipodystrophy

Identifiers

PMID36755585
PMCPMC9900266
OpenAlexW4318407331

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.