ArticleMultiple sclerosis (Houndmills, Basingstoke, England)2023
Personalized monitoring of ambulatory function with a smartphone 2-minute walk test in multiple sclerosis.
Article in Multiple sclerosis (Houndmills, Basingstoke, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 7 citations in OpenAlex.
- Digital monitoring of disease activity in relapsing-remitting multiple sclerosis.Journal of neurology · 2026Article
- Sensors in Multiple Sclerosis.Current neurology and neuroscience reports · 2025Review
- Longitudinal Digital Phenotyping of Multiple Sclerosis Severity Using Passively Sensed Behaviors and Ecological Momentary Assessments: Real-World Evaluation.Journal of medical Internet research · 2025Article
- Psychometric Characteristics of Smartphone-Based Gait Analyses in Chronic Health Conditions: A Systematic Review.Journal of functional morphology and kinesiology · 2025Review
- Digital outcome measures are associated with brain atrophy in patients with multiple sclerosis.Journal of neurology · 2024Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRemote smartphone-based 2-minute walking tests (s2MWTs) allow frequent and potentially sensitive measurements of ambulatory function.
objectiveTo investigate the s2MWT on assessment of, and responsiveness to change in ambulatory function in MS.
methodsOne hundred two multiple sclerosis (MS) patients and 24 healthy controls (HCs) performed weekly s2MWTs on self-owned smartphones for 12 and 3 months, respectively. The timed 25-foot walk test (T25FW) and Expanded Disability Status Scale (EDSS) were assessed at 3-month intervals. Anchor-based (using T25FW and EDSS) and distribution-based (curve fitting) methods were used to assess responsiveness of the s2MWT. A local linear trend model was used to fit weekly s2MWT scores of individual patients.
resultsA total of 4811 and 355 s2MWT scores were obtained in patients (
conclusionsIn group-level analyses, clinically relevant change was insufficiently detected due to large variability with sporadic measurements. Individual-level curve fitting reduced the variability in s2MWT, enabling the detection of statistically reliable change in ambulatory function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.