ArticleNature2023
Telomere-to-mitochondria signalling by ZBP1 mediates replicative crisis.
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Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 112 papers.
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112citing papers in PubMed
30.6field-weighted citation impact, top 1% of its field
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Who cites it
112 citing papers in PubMed, 184 citations in OpenAlex.
- Biological consequences of Z-nucleic acid sensing by ZBP1 and ADAR1.RNA biology · 2026Review
- Two dipeptide repeat proteins are produced from mammalian telomeric RNA previously thought to be a long non-coding RNA.RNA biology · 2026Review
- How telomere attrition protects against cancer.Nature reviews. Genetics · 2026Review
- ZBP1 specifically binds pre-formed Z-RNA, limiting its potential pool of nucleic acid ligands compared to ADAR1.Nucleic acids research · 2026Article
- Mechanisms, regulation and clinical relevance of necroptosis.Nature reviews. Molecular cell biology · 2026Review
- The Role of cGAS-STING-Driven PANoptosis in Neurodegenerative Diseases and Therapeutic Prospects.Cells · 2026Review
- Fragmentation patterns of human telomeric chromatin in plasma cfDNA.Nature communications · 2026Article
- Deconvoluting the multi-faceted roles of alternative splicing events in cancer: From underlying mechanisms to innovative therapeutics.Acta pharmaceutica Sinica. B · 2026Review
- STING deficiency does not rescue short telomere-mediated aging phenotypes and longevity in TERC- or TERT-telomerase deficient mice.Cell reports · 2026Article
- TRF2 couples muscle stem cell identity to regenerative repair.Science advances · 2026Article
- Molecular and functional characterization of telomeric repeat-containing RNAs in Chinese hamster ovary cells.Nucleic acids research · 2026Article
- Aging and cancer: current understandings and future perspectives.Signal transduction and targeted therapy · 2026Review
- Adaptable Covalent Organic Framework-Hydrogel Microneedles for Glucose-Responsive Isoliquiritigenin Delivery in Diabetic Wound Therapy.Advanced healthcare materials · 2026Article
- ZBP1-driven pyroptosis-associated alveolar macrophages exacerbate epithelial dysfunction in sepsis.Cell death & disease · 2026Article
- Z-nucleic acid-mediated PANoptosis in infection, inflammation, and cancer.Communications biology · 2026Review
- Associations between carotenoids and rheumatoid arthritis risk: evidence from two population-based studies.Nutrition journal · 2026Article
- Vascular Aging.Circulation · 2026Review
- Zα and Zβ domains of ADAR1 and ZBP1 bind G-quadruplexes with nanomolar affinities, establishing Zβ as a G-quadruplex-specific domain.Nucleic acids research · 2026Article
- ZBP1's Inability to Convert Unmodified RNAs to the Z-form Underlies a Balanced Mechanism of RNA Recognition with ADAR1.bioRxiv : the preprint server for biology · 2026Article
- Integration of multi-omics and single-cell analysis reveals ZBP1 as a prognostic biomarker of renal cell carcinoma.Scientific reports · 2026Article
52 more citing papers are in PubMed but not listed here.
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Authors and funding
14 authors at 2 institutions in 3 countries.
Joe NassourThe Salk Institute for Biological Studies, La Jolla, CA, USA.
Lucia Gutierrez AguiarThe Salk Institute for Biological Studies, La Jolla, CA, USA.
Adriana CorreiaThe Salk Institute for Biological Studies, La Jolla, CA, USA.
Tobias T SchmidtThe Salk Institute for Biological Studies, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-9064-6192
Laura MainzThe Salk Institute for Biological Studies, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-3986-7547
Sara PrzetockaThe Salk Institute for Biological Studies, La Jolla, CA, USA.ORCID http://orcid.org/0000-0001-9143-8152
Candy HaggblomThe Salk Institute for Biological Studies, La Jolla, CA, USA.
Nimesha TadepalleThe Salk Institute for Biological Studies, La Jolla, CA, USA.
April WilliamsThe Salk Institute for Biological Studies, La Jolla, CA, USA.ORCID http://orcid.org/0000-0001-9281-8528
Maxim N ShokhirevThe Salk Institute for Biological Studies, La Jolla, CA, USA.
Semih C AkincilarA*STAR Division of Cancer Genetics, Institute of Molecular and Cell Biology (IMCB), Singapore, Singapore.ORCID http://orcid.org/0000-0001-7588-2771
Vinay TergaonkarA*STAR Division of Cancer Genetics, Institute of Molecular and Cell Biology (IMCB), Singapore, Singapore.
Gerald S ShadelThe Salk Institute for Biological Studies, La Jolla, CA, USA. gshadel@salk.edu.ORCID http://orcid.org/0000-0003-2899-8717
Jan KarlsederThe Salk Institute for Biological Studies, La Jolla, CA, USA. karlseder@salk.edu.ORCID http://orcid.org/0000-0001-7433-9750
Salk Institute for Biological Studies · USAgency for Science, Technology and Research · SG
Funding
Viral Vector Core (VVC)P30CA014195 · NCI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI Ye Zheng · 1985 to 2026
$82.8MProject 4: Interrogating and harnessing age-related IFN signaling and innate immunity in HCC prevention and therapyP01AG073084 · NIA · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI PETER D. ADAMS, GERALD SHADEL · 2021 to 2026
$13.6MSan Diego Nathan Shock CenterP30AG068635 · NIA · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI SHADEL, GERALD · 2020 to 2024
$6.0MHigh-throughput mapping of selectively vulnerable cell types and projections in aging and Alzheimer's DiseaseRF1AG064049 · NIA · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI LEE, KUO-FEN, ZADOR, ANTHONY M · 2019 to 2019
$4.7MXERODERMA PIGMENTOSUM VARIANT--GENETIC ANALYSIS AND GENE MAPPINGP30AR041940 · NIAMS · UNIVERSITY OF TEXAS SW MED CTR/DALLAS · PI BERGSTRESSER, PAUL R · 1992 to 2005
$3.7MUnderstanding the role of autophagy-regulated cell death in the escape from replicative crisisR01CA234047 · NCI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI KARLSEDER, JAN, SHAW, REUBEN · 2020 to 2024
$3.1MA nucleus-to-mitochondria nucleic acid-sensing pathway prevents bypass of age-associated proliferative boundariesR01AG077324 · NIA · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI Jan Karlseder · 2022 to 2026
$3.0MMitochondria-to-Nucleus Signaling in Colorectal CancerR01CA228211 · NCI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI HARGREAVES, DIANA CLARE, SHADEL, GERALD · 2020 to 2024
$2.6MUnderstanding DNA break repair pathway choice regulation by the cNHEJ inhibitor CYRENR01CA227934 · NCI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI KARLSEDER, JAN · 2018 to 2022
$2.2MMitochondrial DNA Stress Activation of Interferon Signaling and Lupus PathologyR01AR069876 · NIAMS · YALE UNIVERSITY · PI SHADEL, GERALD · 2017 to 2021
$2.1MThe role of autophagy in the escape from replicative crisis and tumorigenesisK99CA252447 · NCI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI NASSOUR, JOE · 2020 to 2021
$326kNCI NIH HHS K99 CA252447NCI NIH HHS P30 CA014195NCI NIH HHS R01 CA227934NCI NIH HHS R01 CA228211NCI NIH HHS R01 CA234047NIAMS NIH HHS P30 AR041940NIAMS NIH HHS R01 AR069876NIA NIH HHS P01 AG073084NIA NIH HHS P30 AG068635NIA NIH HHS R01 AG077324NIA NIH HHS RF1 AG064049
Abstract
Cancers arise through the accumulation of genetic and epigenetic alterations that enable cells to evade telomere-based proliferative barriers and achieve immortality. One such barrier is replicative crisis-an autophagy-dependent program that eliminates checkpoint-deficient cells with unstable telomeres and other cancer-relevant chromosomal aberrations
Indexed as
DNA ReplicationMitochondriaSignal TransductionTelomereAdaptor Proteins, Signal TransducingAutophagyCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseDNAHumansImmunity, InnateInterferonsNeoplasmsRNA-Binding ProteinsRNA, Long NoncodingSTING ProteinAdaptor Proteins, Signal TransducingcGAS protein, humanCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseDNAInterferonsMAVS protein, humanRNA-Binding ProteinsRNA, Long NoncodingSTING1 protein, humanSTING ProteinZBP1 protein, human
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