Evidence map›Paper›PMID 36754907›Full record

ArticleJournal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing2023

Validation of the SCALE-CryoAF risk model to predict very late return of atrial fibrillation after cryoballoon ablation.

Tanvi Nayak, Graham Peigh, Alexandru B Chicos, Rishi Arora, Susan Kim, Albert Lin, Nishant Verma, Anna Pfenniger, Kaustubha D Patil, Bradley P Knight and 1 more

Abstract read
In one paragraph

Article in Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Tanvi NayakFeinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Graham PeighDivision of Cardiology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Alexandru B ChicosDivision of Cardiology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Rishi AroraDivision of Cardiology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Susan KimDivision of Cardiology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Albert LinDivision of Cardiology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Nishant VermaDivision of Cardiology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Anna PfennigerDivision of Cardiology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Kaustubha D PatilDivision of Cardiology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Bradley P KnightDivision of Cardiology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Rod S PassmanDivision of Cardiology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. rod.passman@nm.org.ORCID http://orcid.org/0000-0001-8718-1534

Funding

Northwestern University Clinical and Translational Science Institute (NUCATS)KL2TR001424 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SHARMA, LEENA · 2015 to 2023
$8.1M
New and Disruptive Therapeutic Approaches to Target Fundamental Molecular Mechanisms Underlying Atrial FibrillationR35HL161249 · NHLBI · UNIVERSITY OF CHICAGO · PI Rishi Arora · 2022 to 2026
$5.1M
NCATS NIH HHS KL2 TR001424NHLBI NIH HHS R35 HL161249
6 · The paper itself

Abstract

backgroundTo date, few risk models have been validated to predict recurrent atrial fibrillation (AF) >1 year after ablation. The SCALE-CryoAF score was previously derived to predict very late return of AF (VLRAF) >1 year following cryoballoon ablation (CBA), with strong predictive ability. In this study, we aim to validate the SCALE-CryoAF score for VLRAF after CBA in a novel patient cohort.

methodsRetrospective analysis of a prospectively maintained single-center database was performed. Inclusion criteria were pulmonary vein isolation using CBA 2017-2020. Exclusion criteria included prior ablation, <1-year follow-up, lack of pre-CBA echocardiogram, additional ablation lesion sets, and documented AF recurrence 90-365 days post-CBA. The area under the curve (AUC) of SCALE-CryoAF was compared to the derivation value and other established risk models.

resultsAmong 469 CBA performed, 241 (61% male, 62.8 ±11.7 years old) cases were included in analysis. There were 37 (15.4%) patients who developed VLRAF. Patients with VLRAF had a higher SCALE-CryoAF score (VLRAF 5.4 ± 2.7; no VLRAF 3.1 ± 2.9; p<0.001). SCALE-CryoAF was linearly associated with VLRAF (y=14.35x-11.72, R

conclusionsThe current analysis validates the ability of SCALE-CryoAF to predict VLRAF after CBA in a novel patient cohort. Patients with a high SCALE-CryoAF score should be monitored closely for recurrent AF >1 year following CBA.

Indexed as

Atrial FibrillationCatheter AblationCryosurgeryPulmonary VeinsAgedEchocardiographyFemaleHumansMaleMiddle AgedRecurrenceRetrospective StudiesRisk FactorsTreatment OutcomeAtrial fibrillationCryoballoon ablationRisk score

Identifiers

PMID36754907
PMCPMC9908502

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.