Evidence map›Paper›PMID 36754776›Full record

ArticleInternational dental journal2023

A Novel Antimicrobial Hydrogel for the Management of Periodontal Diseases.

Pauline Yang Wong, Shane Soo, Edmund Soon-Chern Wong, Praveen Praveen, Peta Clode, Murray V Baker, Victor Haruo Matsubara

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International dental journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. [Latest Findings on Hydrogel Drug Delivery Systems in the Treatment of Periodontitis].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Pauline Yang WongUWA Dental School, The University of Western Australia, Perth, Western Australia, Australia.
Shane SooUWA Dental School, The University of Western Australia, Perth, Western Australia, Australia.
Edmund Soon-Chern WongUWA Dental School, The University of Western Australia, Perth, Western Australia, Australia.
Praveen PraveenSchool of Molecular Sciences, The University of Western Australia, Perth, Western Australia, Australia.
Peta ClodeCentre for Microscopy, Characterisation, and Analysis and School of Biological Sciences, The University of Western Australia, Perth, Western Australia, Australia.
Murray V BakerSchool of Molecular Sciences, The University of Western Australia, Perth, Western Australia, Australia.
Victor Haruo MatsubaraUWA Dental School, The University of Western Australia, Perth, Western Australia, Australia.
The University of Western Australia · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThis study aimed to synthesise a drug-delivery system based on a porous polymer hydrogel, with antimicrobial properties against Porphyromonas gingivalis and potential to be used in tissue regeneration. MATERIAL AND

methods2-Hydroxyethyl methacrylate monomers were polymerised using thermal and photoactivation in the presence of silver nitrate (AgNO

resultsOur methodology manufactured porous polymeric hydrogels doped with AgNPs and CHX. Hydrogels showed a successful delivery of CHX and sustainable release of AgNPs in a steady hydrogel degradation rate determined based on the weight loss of samples. Hydrogels with AgNPs or CHX had a significant antimicrobial effect against P. gingivalis, with CHX-hydrogels exhibiting a stronger effect than AgNP-hydrogels in the short-term assessment. AgNP-CHX hydrogels showed a compounded antimicrobial effect, whereas control hydrogels containing neither AgNPs nor CHX had no influence on bacterial growth (P < .05).

conclusionsThe dual-cured pHEMA hydrogel loaded with antimicrobial agents proved to be an efficient drug-delivery system against periodontopathogens, with the potential to be used as a scaffold for tissue regeneration.

Indexed as

Anti-Infective AgentsMetal NanoparticlesPeriodontal DiseasesAnti-Bacterial AgentsHumansHydrogelsMethacrylatesPolyhydroxyethyl MethacrylateSilverAnti-Bacterial AgentsAnti-Infective AgentsHydrogelshydroxyethyl methacrylateMethacrylatesPolyhydroxyethyl MethacrylateSilverAntimicrobial agentChlorhexidineHydrogelSilver nanoparticlesTissue scaffolds

Identifiers

PMID36754776
PMCPMC10213806
OpenAlexW4319304415

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.