Evidence map›Paper›PMID 36754682›Full record

ArticleTrends in biochemical sciences2023

CryoEM shows the active dynein complex on microtubules.

Sharon R Garrott, Morgan E DeSantis

Abstract readComment
PubMed Publisher
In one paragraph

Article in Trends in biochemical sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Sharon R GarrottDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA; Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.
Morgan E DeSantisDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA; Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: mdesant@umich.edu.

Funding

Mechanisms of Lis1 and NudE/L Regulation of the Molecular Motor DyneinR00GM127757 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DESANTIS, MORGAN · 2020 to 2022
$747k
6 · The paper itself

Abstract

In a recent study, Chaaban and Carter use cryo-electron microscopy (cryo-EM) and an innovative data-processing pipeline to determine the first high-resolution structure of the dynein-dynactin-BICDR1 complex assembled on microtubules. The structure of the complex reveals novel stoichiometry and provides new mechanistic insight into dynein function and mechanism.

Indexed as

DyneinsMicrotubule-Associated ProteinsCryoelectron MicroscopyDynactin ComplexMicrotubulesDynactin ComplexDyneinsMicrotubule-Associated Proteinscryo-electron microscopycytoplasmic-dynein 1dynactinmicrotubules

Identifiers

PMID36754682

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.