Observational studyNeurology2023
Association of Employment Status With Symptom Burden and Health-Related Quality of Life in People Living With Primary CNS Tumors.
Open access · greenAbstract readObservational Study
In one paragraph
Observational study in Neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
7.4field-weighted citation impact, top 3% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 13 citations in OpenAlex.
- Symptom burden in young adult brain tumor survivors: Key intervention targets based on patient-reported outcome network analyses.Neuro-oncology practice · 2026Article
- Natural history study of adults with primary central nervous system tumors: Initial results for first 1000 participants.Neuro-oncology practice · 2026Article
- Post-diagnosis unemployment and access to work-related health benefits in survivors of brain cancer compared to other cancers.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Structural organization of neurosurgical care and its influence on long-term outcomes in glioma: evidence from a large single-center cohort in China.Journal of neuro-oncology · 2026Article
- Identifying sleep disturbance- and fatigue-related factors of poor health-related quality of life in patients with advanced ovarian cancer.Journal of patient-reported outcomes · 2026Article
- Implications of sociodemographic and clinical factors on symptom burden: Age-specific survivorship care in the primary central nervous system tumor population.Neuro-oncology practice · 2025Article
- The Interplay of Chronic Stress and Cancer: Pathophysiology and Implications for Integrated Care.Cancer reports (Hoboken, N.J.) · 2025Review
- Financial toxicity of oral chemotherapy in patients with primary brain tumors.Neuro-oncology practice · 2025Article
- Financial challenges of being on long-term, high-cost medications.Neuro-oncology practice · 2025Review
- Risk factors, predictive models, and general work ability trajectory in patients with glioma.Neuro-oncology advancesArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
25 authors at 1 institution in 1 country.
Heather E LeeperFrom the Neuro-Oncology Branch (H.E.L., E.V., A. Christ, A.A., N.B., A. Choi, E.G., V.J., M.L., J.R., K.N.R., J.L.R., M.T., E.B., M.P.-P., V.P., L.P., B.J.T., J.W., M.R.G., T.S.A.), and Office of Information Technology (J.L.), Center for Cancer Research, National Cancer Institute, NIH, Bethesda; Leidos Biomedical Research (L.B., M.P.), Frederick National Laboratory for Cancer Research Sponsored by the National Cancer Institute, MD; Concentric Methods, LLC (N.L.), Manassas, VA; and Department of Neurology (B.J.T.), Uniformed Services University of the Health Sciences, Bethesda, MD. hleeper@uchicagomedicine.org.ORCID 0000-0003-2840-611X
Elizabeth VeraFrom the Neuro-Oncology Branch (H.E.L., E.V., A. Christ, A.A., N.B., A. Choi, E.G., V.J., M.L., J.R., K.N.R., J.L.R., M.T., E.B., M.P.-P., V.P., L.P., B.J.T., J.W., M.R.G., T.S.A.), and Office of Information Technology (J.L.), Center for Cancer Research, National Cancer Institute, NIH, Bethesda; Leidos Biomedical Research (L.B., M.P.), Frederick National Laboratory for Cancer Research Sponsored by the National Cancer Institute, MD; Concentric Methods, LLC (N.L.), Manassas, VA; and Department of Neurology (B.J.T.), Uniformed Services University of the Health Sciences, Bethesda, MD.
Alexa ChristFrom the Neuro-Oncology Branch (H.E.L., E.V., A. Christ, A.A., N.B., A. Choi, E.G., V.J., M.L., J.R., K.N.R., J.L.R., M.T., E.B., M.P.-P., V.P., L.P., B.J.T., J.W., M.R.G., T.S.A.), and Office of Information Technology (J.L.), Center for Cancer Research, National Cancer Institute, NIH, Bethesda; Leidos Biomedical Research (L.B., M.P.), Frederick National Laboratory for Cancer Research Sponsored by the National Cancer Institute, MD; Concentric Methods, LLC (N.L.), Manassas, VA; and Department of Neurology (B.J.T.), Uniformed Services University of the Health Sciences, Bethesda, MD.
Alvina AcquayeFrom the Neuro-Oncology Branch (H.E.L., E.V., A. Christ, A.A., N.B., A. Choi, E.G., V.J., M.L., J.R., K.N.R., J.L.R., M.T., E.B., M.P.-P., V.P., L.P., B.J.T., J.W., M.R.G., T.S.A.), and Office of Information Technology (J.L.), Center for Cancer Research, National Cancer Institute, NIH, Bethesda; Leidos Biomedical Research (L.B., M.P.), Frederick National Laboratory for Cancer Research Sponsored by the National Cancer Institute, MD; Concentric Methods, LLC (N.L.), Manassas, VA; and Department of Neurology (B.J.T.), Uniformed Services University of the Health Sciences, Bethesda, MD.
Nicole BricenoFrom the Neuro-Oncology Branch (H.E.L., E.V., A. Christ, A.A., N.B., A. Choi, E.G., V.J., M.L., J.R., K.N.R., J.L.R., M.T., E.B., M.P.-P., V.P., L.P., B.J.T., J.W., M.R.G., T.S.A.), and Office of Information Technology (J.L.), Center for Cancer Research, National Cancer Institute, NIH, Bethesda; Leidos Biomedical Research (L.B., M.P.), Frederick National Laboratory for Cancer Research Sponsored by the National Cancer Institute, MD; Concentric Methods, LLC (N.L.), Manassas, VA; and Department of Neurology (B.J.T.), Uniformed Services University of the Health Sciences, Bethesda, MD.
Anna ChoiFrom the Neuro-Oncology Branch (H.E.L., E.V., A. Christ, A.A., N.B., A. Choi, E.G., V.J., M.L., J.R., K.N.R., J.L.R., M.T., E.B., M.P.-P., V.P., L.P., B.J.T., J.W., M.R.G., T.S.A.), and Office of Information Technology (J.L.), Center for Cancer Research, National Cancer Institute, NIH, Bethesda; Leidos Biomedical Research (L.B., M.P.), Frederick National Laboratory for Cancer Research Sponsored by the National Cancer Institute, MD; Concentric Methods, LLC (N.L.), Manassas, VA; and Department of Neurology (B.J.T.), Uniformed Services University of the Health Sciences, Bethesda, MD.
Ewa GrajkowskaFrom the Neuro-Oncology Branch (H.E.L., E.V., A. Christ, A.A., N.B., A. Choi, E.G., V.J., M.L., J.R., K.N.R., J.L.R., M.T., E.B., M.P.-P., V.P., L.P., B.J.T., J.W., M.R.G., T.S.A.), and Office of Information Technology (J.L.), Center for Cancer Research, National Cancer Institute, NIH, Bethesda; Leidos Biomedical Research (L.B., M.P.), Frederick National Laboratory for Cancer Research Sponsored by the National Cancer Institute, MD; Concentric Methods, LLC (N.L.), Manassas, VA; and Department of Neurology (B.J.T.), Uniformed Services University of the Health Sciences, Bethesda, MD.
Varna JammulaFrom the Neuro-Oncology Branch (H.E.L., E.V., A. Christ, A.A., N.B., A. Choi, E.G., V.J., M.L., J.R., K.N.R., J.L.R., M.T., E.B., M.P.-P., V.P., L.P., B.J.T., J.W., M.R.G., T.S.A.), and Office of Information Technology (J.L.), Center for Cancer Research, National Cancer Institute, NIH, Bethesda; Leidos Biomedical Research (L.B., M.P.), Frederick National Laboratory for Cancer Research Sponsored by the National Cancer Institute, MD; Concentric Methods, LLC (N.L.), Manassas, VA; and Department of Neurology (B.J.T.), Uniformed Services University of the Health Sciences, Bethesda, MD.
Jason LevineFrom the Neuro-Oncology Branch (H.E.L., E.V., A. Christ, A.A., N.B., A. Choi, E.G., V.J., M.L., J.R., K.N.R., J.L.R., M.T., E.B., M.P.-P., V.P., L.P., B.J.T., J.W., M.R.G., T.S.A.), and Office of Information Technology (J.L.), Center for Cancer Research, National Cancer Institute, NIH, Bethesda; Leidos Biomedical Research (L.B., M.P.), Frederick National Laboratory for Cancer Research Sponsored by the National Cancer Institute, MD; Concentric Methods, LLC (N.L.), Manassas, VA; and Department of Neurology (B.J.T.), Uniformed Services University of the Health Sciences, Bethesda, MD.
Matthew LindsleyFrom the Neuro-Oncology Branch (H.E.L., E.V., A. Christ, A.A., N.B., A. Choi, E.G., V.J., M.L., J.R., K.N.R., J.L.R., M.T., E.B., M.P.-P., V.P., L.P., B.J.T., J.W., M.R.G., T.S.A.), and Office of Information Technology (J.L.), Center for Cancer Research, National Cancer Institute, NIH, Bethesda; Leidos Biomedical Research (L.B., M.P.), Frederick National Laboratory for Cancer Research Sponsored by the National Cancer Institute, MD; Concentric Methods, LLC (N.L.), Manassas, VA; and Department of Neurology (B.J.T.), Uniformed Services University of the Health Sciences, Bethesda, MD.
Jennifer ReyesFrom the Neuro-Oncology Branch (H.E.L., E.V., A. Christ, A.A., N.B., A. Choi, E.G., V.J., M.L., J.R., K.N.R., J.L.R., M.T., E.B., M.P.-P., V.P., L.P., B.J.T., J.W., M.R.G., T.S.A.), and Office of Information Technology (J.L.), Center for Cancer Research, National Cancer Institute, NIH, Bethesda; Leidos Biomedical Research (L.B., M.P.), Frederick National Laboratory for Cancer Research Sponsored by the National Cancer Institute, MD; Concentric Methods, LLC (N.L.), Manassas, VA; and Department of Neurology (B.J.T.), Uniformed Services University of the Health Sciences, Bethesda, MD.
Kayla N RocheFrom the Neuro-Oncology Branch (H.E.L., E.V., A. Christ, A.A., N.B., A. Choi, E.G., V.J., M.L., J.R., K.N.R., J.L.R., M.T., E.B., M.P.-P., V.P., L.P., B.J.T., J.W., M.R.G., T.S.A.), and Office of Information Technology (J.L.), Center for Cancer Research, National Cancer Institute, NIH, Bethesda; Leidos Biomedical Research (L.B., M.P.), Frederick National Laboratory for Cancer Research Sponsored by the National Cancer Institute, MD; Concentric Methods, LLC (N.L.), Manassas, VA; and Department of Neurology (B.J.T.), Uniformed Services University of the Health Sciences, Bethesda, MD.
James L RogersFrom the Neuro-Oncology Branch (H.E.L., E.V., A. Christ, A.A., N.B., A. Choi, E.G., V.J., M.L., J.R., K.N.R., J.L.R., M.T., E.B., M.P.-P., V.P., L.P., B.J.T., J.W., M.R.G., T.S.A.), and Office of Information Technology (J.L.), Center for Cancer Research, National Cancer Institute, NIH, Bethesda; Leidos Biomedical Research (L.B., M.P.), Frederick National Laboratory for Cancer Research Sponsored by the National Cancer Institute, MD; Concentric Methods, LLC (N.L.), Manassas, VA; and Department of Neurology (B.J.T.), Uniformed Services University of the Health Sciences, Bethesda, MD.
Michael TimmerFrom the Neuro-Oncology Branch (H.E.L., E.V., A. Christ, A.A., N.B., A. Choi, E.G., V.J., M.L., J.R., K.N.R., J.L.R., M.T., E.B., M.P.-P., V.P., L.P., B.J.T., J.W., M.R.G., T.S.A.), and Office of Information Technology (J.L.), Center for Cancer Research, National Cancer Institute, NIH, Bethesda; Leidos Biomedical Research (L.B., M.P.), Frederick National Laboratory for Cancer Research Sponsored by the National Cancer Institute, MD; Concentric Methods, LLC (N.L.), Manassas, VA; and Department of Neurology (B.J.T.), Uniformed Services University of the Health Sciences, Bethesda, MD.
Lisa BorisFrom the Neuro-Oncology Branch (H.E.L., E.V., A. Christ, A.A., N.B., A. Choi, E.G., V.J., M.L., J.R., K.N.R., J.L.R., M.T., E.B., M.P.-P., V.P., L.P., B.J.T., J.W., M.R.G., T.S.A.), and Office of Information Technology (J.L.), Center for Cancer Research, National Cancer Institute, NIH, Bethesda; Leidos Biomedical Research (L.B., M.P.), Frederick National Laboratory for Cancer Research Sponsored by the National Cancer Institute, MD; Concentric Methods, LLC (N.L.), Manassas, VA; and Department of Neurology (B.J.T.), Uniformed Services University of the Health Sciences, Bethesda, MD.
Eric BurtonFrom the Neuro-Oncology Branch (H.E.L., E.V., A. Christ, A.A., N.B., A. Choi, E.G., V.J., M.L., J.R., K.N.R., J.L.R., M.T., E.B., M.P.-P., V.P., L.P., B.J.T., J.W., M.R.G., T.S.A.), and Office of Information Technology (J.L.), Center for Cancer Research, National Cancer Institute, NIH, Bethesda; Leidos Biomedical Research (L.B., M.P.), Frederick National Laboratory for Cancer Research Sponsored by the National Cancer Institute, MD; Concentric Methods, LLC (N.L.), Manassas, VA; and Department of Neurology (B.J.T.), Uniformed Services University of the Health Sciences, Bethesda, MD.
Nicole LolloFrom the Neuro-Oncology Branch (H.E.L., E.V., A. Christ, A.A., N.B., A. Choi, E.G., V.J., M.L., J.R., K.N.R., J.L.R., M.T., E.B., M.P.-P., V.P., L.P., B.J.T., J.W., M.R.G., T.S.A.), and Office of Information Technology (J.L.), Center for Cancer Research, National Cancer Institute, NIH, Bethesda; Leidos Biomedical Research (L.B., M.P.), Frederick National Laboratory for Cancer Research Sponsored by the National Cancer Institute, MD; Concentric Methods, LLC (N.L.), Manassas, VA; and Department of Neurology (B.J.T.), Uniformed Services University of the Health Sciences, Bethesda, MD.
Marissa PanzerFrom the Neuro-Oncology Branch (H.E.L., E.V., A. Christ, A.A., N.B., A. Choi, E.G., V.J., M.L., J.R., K.N.R., J.L.R., M.T., E.B., M.P.-P., V.P., L.P., B.J.T., J.W., M.R.G., T.S.A.), and Office of Information Technology (J.L.), Center for Cancer Research, National Cancer Institute, NIH, Bethesda; Leidos Biomedical Research (L.B., M.P.), Frederick National Laboratory for Cancer Research Sponsored by the National Cancer Institute, MD; Concentric Methods, LLC (N.L.), Manassas, VA; and Department of Neurology (B.J.T.), Uniformed Services University of the Health Sciences, Bethesda, MD.
Marta Penas-PradoFrom the Neuro-Oncology Branch (H.E.L., E.V., A. Christ, A.A., N.B., A. Choi, E.G., V.J., M.L., J.R., K.N.R., J.L.R., M.T., E.B., M.P.-P., V.P., L.P., B.J.T., J.W., M.R.G., T.S.A.), and Office of Information Technology (J.L.), Center for Cancer Research, National Cancer Institute, NIH, Bethesda; Leidos Biomedical Research (L.B., M.P.), Frederick National Laboratory for Cancer Research Sponsored by the National Cancer Institute, MD; Concentric Methods, LLC (N.L.), Manassas, VA; and Department of Neurology (B.J.T.), Uniformed Services University of the Health Sciences, Bethesda, MD.
Valentina PillaiFrom the Neuro-Oncology Branch (H.E.L., E.V., A. Christ, A.A., N.B., A. Choi, E.G., V.J., M.L., J.R., K.N.R., J.L.R., M.T., E.B., M.P.-P., V.P., L.P., B.J.T., J.W., M.R.G., T.S.A.), and Office of Information Technology (J.L.), Center for Cancer Research, National Cancer Institute, NIH, Bethesda; Leidos Biomedical Research (L.B., M.P.), Frederick National Laboratory for Cancer Research Sponsored by the National Cancer Institute, MD; Concentric Methods, LLC (N.L.), Manassas, VA; and Department of Neurology (B.J.T.), Uniformed Services University of the Health Sciences, Bethesda, MD.
Lily PolskinFrom the Neuro-Oncology Branch (H.E.L., E.V., A. Christ, A.A., N.B., A. Choi, E.G., V.J., M.L., J.R., K.N.R., J.L.R., M.T., E.B., M.P.-P., V.P., L.P., B.J.T., J.W., M.R.G., T.S.A.), and Office of Information Technology (J.L.), Center for Cancer Research, National Cancer Institute, NIH, Bethesda; Leidos Biomedical Research (L.B., M.P.), Frederick National Laboratory for Cancer Research Sponsored by the National Cancer Institute, MD; Concentric Methods, LLC (N.L.), Manassas, VA; and Department of Neurology (B.J.T.), Uniformed Services University of the Health Sciences, Bethesda, MD.
Brett J TheelerFrom the Neuro-Oncology Branch (H.E.L., E.V., A. Christ, A.A., N.B., A. Choi, E.G., V.J., M.L., J.R., K.N.R., J.L.R., M.T., E.B., M.P.-P., V.P., L.P., B.J.T., J.W., M.R.G., T.S.A.), and Office of Information Technology (J.L.), Center for Cancer Research, National Cancer Institute, NIH, Bethesda; Leidos Biomedical Research (L.B., M.P.), Frederick National Laboratory for Cancer Research Sponsored by the National Cancer Institute, MD; Concentric Methods, LLC (N.L.), Manassas, VA; and Department of Neurology (B.J.T.), Uniformed Services University of the Health Sciences, Bethesda, MD.
Jing WuFrom the Neuro-Oncology Branch (H.E.L., E.V., A. Christ, A.A., N.B., A. Choi, E.G., V.J., M.L., J.R., K.N.R., J.L.R., M.T., E.B., M.P.-P., V.P., L.P., B.J.T., J.W., M.R.G., T.S.A.), and Office of Information Technology (J.L.), Center for Cancer Research, National Cancer Institute, NIH, Bethesda; Leidos Biomedical Research (L.B., M.P.), Frederick National Laboratory for Cancer Research Sponsored by the National Cancer Institute, MD; Concentric Methods, LLC (N.L.), Manassas, VA; and Department of Neurology (B.J.T.), Uniformed Services University of the Health Sciences, Bethesda, MD.
Mark R GilbertFrom the Neuro-Oncology Branch (H.E.L., E.V., A. Christ, A.A., N.B., A. Choi, E.G., V.J., M.L., J.R., K.N.R., J.L.R., M.T., E.B., M.P.-P., V.P., L.P., B.J.T., J.W., M.R.G., T.S.A.), and Office of Information Technology (J.L.), Center for Cancer Research, National Cancer Institute, NIH, Bethesda; Leidos Biomedical Research (L.B., M.P.), Frederick National Laboratory for Cancer Research Sponsored by the National Cancer Institute, MD; Concentric Methods, LLC (N.L.), Manassas, VA; and Department of Neurology (B.J.T.), Uniformed Services University of the Health Sciences, Bethesda, MD.
Terri S ArmstrongFrom the Neuro-Oncology Branch (H.E.L., E.V., A. Christ, A.A., N.B., A. Choi, E.G., V.J., M.L., J.R., K.N.R., J.L.R., M.T., E.B., M.P.-P., V.P., L.P., B.J.T., J.W., M.R.G., T.S.A.), and Office of Information Technology (J.L.), Center for Cancer Research, National Cancer Institute, NIH, Bethesda; Leidos Biomedical Research (L.B., M.P.), Frederick National Laboratory for Cancer Research Sponsored by the National Cancer Institute, MD; Concentric Methods, LLC (N.L.), Manassas, VA; and Department of Neurology (B.J.T.), Uniformed Services University of the Health Sciences, Bethesda, MD.
MACOM (United States) · US
Funding
Natural History and Specimen Banking for Patients with CNS TumorsZIABC011768 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI ARMSTRONG, TERRI S. · 2017 to 2024
$6.7MIntramural NIH HHS ZIA BC011768
Abstract
BACKGROUND AND
objectivesFinancial toxicity significantly affects many patients, especially cancer survivors. We evaluated the association of unemployment as a major contributor to financial toxicity with patient-reported outcomes (PROs) assessing multiple illness experience domains in a primary CNS tumor (PCNST) cohort.
methodsPatient and disease characteristics and PROs measuring symptom burden, interference, psychologic distress, functional impairment, and health-related quality of life (HRQOL) from participants enrolled in an institutional review board-approved observational study at the US NIH's Neuro-Oncology Branch were collected between September 2016 and December 2019. Descriptive statistics, tests of association, and comparison of group mean values were used to describe and evaluate PROs.
resultsOf the 277 participants diagnosed with a PCNST, 57% were male and 43% were female. Participants reported their race as White, non-Hispanic (78%); White, Hispanic/Latino (9%); Asian (7%); Black (4%); Native Hawaiian/Pacific Islander (1%); and other (2%) with 8% missing. The median age of the overall cohort was 45 years (range 18-74). Hispanic participants in the overall sample were 2.3 times more likely, and in the brain tumor group 3.2 times more likely, to report unemployment ( DISCUSSION: Being unemployed due to a PCNST strongly correlated with high symptom burden, functional impairment, psychological distress, and reduced HRQOL, which may be impediments to returning to work that warrant intervention. Lack of employer-based health insurance and reduced earnings are financial sequelae of unemployment superimposed on the physical, social, and cognitive effects of living with a PCNST. Innovations to screen for and address financial toxicity and its contributing factors are needed.
Indexed as
Brain NeoplasmsQuality of LifeAdolescentAdultAgedAnxietyAnxiety DisordersEmploymentFemaleHumansMaleMiddle AgedYoung Adult
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