Evidence map›Paper›PMID 36754625›Full record

ArticleeNeuro2023

BrainWAVE: A Flexible Method for Noninvasive Stimulation of Brain Rhythms across Species.

Matthew K Attokaren, Nuri Jeong, Lou Blanpain, Abigail L Paulson, Kristie M Garza, Ben Borron, Michael Walelign, Jon Willie, Annabelle C Singer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eNeuro, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Matthew K AttokarenCoulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30322.
Nuri JeongCoulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30322.
Lou BlanpainCoulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30322.
Abigail L PaulsonCoulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30322.
Kristie M GarzaCoulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30322.
Ben BorronCoulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30322.
Michael WalelignCoulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30322.
Jon WillieNeurosurgery, Biomedical Engineering, Psychiatry, Neuroscience and Neurology, Washington University, St Louis, MO 63110.
Annabelle C SingerCoulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30322 asinger@gatech.edu.

Funding

TRAINING IN TRANSLATIONAL RESEARCH IN NEUROLOGYT32NS007480 · NINDS · EMORY UNIVERSITY · PI LEVEY, ALLAN I · 2000 to 2020
$4.5M
Non-Invasive Methods to Drive Neural Activity with Millisecond Precision and to Recruit the Brain’s Immune CellsR01NS109226 · NINDS · GEORGIA INSTITUTE OF TECHNOLOGY · PI Annabelle Catherine Singer · 2018 to 2026
$2.7M
Hippocampal interneurons in novel memory formation in health and Alzheimer's diseaseRF1AG078736 · NIA · GEORGIA INSTITUTE OF TECHNOLOGY · PI SINGER, ANNABELLE CATHERINE · 2022 to 2025
$2.5M
Effects of non-invasive gamma stimulation on hippocampal neural codes in a mouse model of Alzheimer’s diseaseF31AG066410 · NIA · GEORGIA INSTITUTE OF TECHNOLOGY · PI PAULSON, ABIGAIL LYNN · 2019 to 2021
$137k
NIA NIH HHS F31 AG066410NINDS NIH HHS R01 NS109226NINDS NIH HHS T32 NS007480
6 · The paper itself

Abstract

Rhythmic neural activity, which coordinates brain regions and neurons to achieve multiple brain functions, is impaired in many diseases. Despite the therapeutic potential of driving brain rhythms, methods to noninvasively target deep brain regions are limited. Accordingly, we recently introduced a noninvasive stimulation approach using flickering lights and sounds ("flicker"). Flicker drives rhythmic activity in deep and superficial brain regions. Gamma flicker spurs immune function, clears pathogens, and rescues memory performance in mice with amyloid pathology. Here, we present substantial improvements to this approach that is flexible, user-friendly, and generalizable across multiple experimental settings and species. We present novel open-source methods for flicker stimulation across rodents and humans. We demonstrate rapid, cross-species induction of rhythmic activity without behavioral confounds in multiple settings from electrophysiology to neuroimaging. This flicker approach provides an exceptional opportunity to discover the therapeutic effects of brain rhythms across scales and species.

Indexed as

BrainBrain WavesAmyloidAnimalsCognitionHumansMiceNeuronsPhotic StimulationAmyloidbrain oscillationsbrain stimulationentrainmentflickernoninvasive deep brain modulationsensory stimulation

Identifiers

PMID36754625
PMCPMC9979148

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.