Evidence map›Paper›PMID 36754560›Full record

ArticleBMJ open2023

Innovative COVID-19 point-of-care diagnostics suitable for tuberculosis diagnosis: a scoping review protocol.

Seda Yerlikaya, Lydia Marie-Luise Holtgrewe, Tobias Broger, Chris Isaacs, Payam Nahid, Adithya Cattamanchi, Claudia M Denkinger

Open access · goldAbstract read
In one paragraph

Article in BMJ open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Development of a Rapid Automated Point-of-Care Test formedRxiv : the preprint server for health sciences · 2026
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Seda YerlikayaDivision of Infectious Disease and Tropical Medicine, Heidelberg University, Heidelberg, Germany seda.yerlikaya@uni-heidelberg.de.
Lydia Marie-Luise HoltgreweDivision of Infectious Disease and Tropical Medicine, Heidelberg University, Heidelberg, Germany.ORCID 0000-0003-3692-0469
Tobias BrogerDivision of Infectious Disease and Tropical Medicine, Heidelberg University, Heidelberg, Germany.
Chris IsaacsConnected Diagnostics Limited, London, UK.
Payam NahidUCSF Center for Tuberculosis, University of California San Francisco (UCSF), San Francisco, California, USA.
Adithya CattamanchiUCSF Center for Tuberculosis, University of California San Francisco (UCSF), San Francisco, California, USA.
Claudia M DenkingerDivision of Infectious Disease and Tropical Medicine, Heidelberg University, Heidelberg, Germany.
Heidelberg University · DEUniversity of California, San Francisco · USQuest Diagnostics (United Kingdom) · GB

Funding

Rapid Research for Diagnostics Development in TB Network (R2D2 TB Network)U01AI152087 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CATTAMANCHI, ADITHYA, DENKINGER, CLAUDIA MARIA · 2020 to 2024
$19.3M
NIAID NIH HHS U01 AI152087
6 · The paper itself

Abstract

introductionIn 2014, the WHO published high-priority target product profiles (TPPs) for new tuberculosis (TB) diagnostics to align end-user needs with test targets and specifications; nevertheless, no TB test meets these targets to date. The COVID-19-driven momentum in the diagnostics world offers an opportunity to address the long-standing lack of innovation in the field of TB diagnostics. This scoping review aims to summarise point-of-care (POC) molecular and antigen tests for COVID-19 diagnosis that, when applied to TB, potentially meet WHO TPPs. This summary of currently available innovative diagnostic tools will guide the development of novel TB diagnostics toward the WHO-set targets. METHODS AND ANALYSIS: We will follow the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension Scoping Reviews recommendations. MEDLINE (via PubMed), bioRxiv, MedRxiv and other publicly available in vitro diagnostic test databases were searched on 23 November 2022. POC antigen or molecular tests developed for SARS-CoV-2 detection that meet the eligibility criteria will be included in the review. Developer description, test description, operation characteristics, pricing information, performance and commercialisation status of diagnostic tests identified will be extracted using a predefined standardised data extraction form. Two reviewers will independently perform the screening and data extraction. A narrative synthesis of the final data will be provided. ETHICS AND DISSEMINATION: No ethical approval is required because individual patient data will not be included. The findings will be published in open-access scientific journals.

Indexed as

COVID-19TuberculosisCOVID-19 TestingHumansPoint-of-Care TestingResearch DesignSARS-CoV-2Scoping Reviews as TopicCOVID-19Diagnostic microbiologyTuberculosis

Identifiers

PMID36754560
PMCPMC9922875
OpenAlexW4319593034

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.