Evidence map›Paper›PMID 36754514›Full record

SynthesisJournal of the American College of Cardiology2023

P2Y

Felice Gragnano, Roxana Mehran, Mattia Branca, Anna Franzone, Usman Baber, Yangsoo Jang, Takeshi Kimura, Joo-Yong Hahn, Qiang Zhao, Stephan Windecker and 18 more

Open access · greenAbstract readMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Journal of the American College of Cardiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 2 pooled it
24.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 2 syntheses or guidelines pooled it, 110 citations in OpenAlex.

  1. P2YJournal of the American Heart Association · 2025
    Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Review
  6. Review
  7. Review
  8. Two-Year Clinical Outcomes in Patients With Coronary Bifurcation Lesions: Results From the Onyx ONE Clear Study.Journal of the Society for Cardiovascular Angiography & Interventions · 2026
    Article
  9. Duration of dual antiplatelet therapy and risk of stent thrombosis in patients undergoing complex PCI: a meta-analysis.Clinical research in cardiology : official journal of the German Cardiac Society · 2026
    Article
  10. Article
  11. Article
  12. Article
  13. Antithrombotic therapy in complex percutaneous coronary intervention.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2025
    Review
  14. P2YReviews in cardiovascular medicine · 2025
    Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

28 authors at 17 institutions in 10 countries.

Felice GragnanoDepartment of Translational Medical Sciences, University of Campania Luigi Vanvitelli, Caserta, Italy.
Roxana MehranIcahn School of Medicine at Mount Sinai, New York, New York, USA.
Mattia BrancaClinical Trials Unit, Bern, Switzerland.
Anna FranzoneDepartment of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy.
Usman BaberUniversity of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
Yangsoo JangDepartment of Cardiology, CHA Bundang Medical Center, CHA University College of Medicine, Seongnam, South Korea.
Takeshi KimuraKyoto University Graduate School of Medicine, Department of Cardiovascular Medicine, Kyoto, Japan.
Joo-Yong HahnHeart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Qiang ZhaoDepartment of Cardiovascular Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Stephan WindeckerDepartment of Cardiology, Bern University Hospital, University of Bern, Bern, Switzerland.
Charles M GibsonDivision of Cardiology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Byeong-Keuk KimDepartment of Cardiology, CHA Bundang Medical Center, CHA University College of Medicine, Seongnam, South Korea.
Hirotoshi WatanabeKyoto University Graduate School of Medicine, Department of Cardiovascular Medicine, Kyoto, Japan.
Young Bin SongHeart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Yunpeng ZhuDepartment of Cardiovascular Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Pascal VranckxDepartment of Cardiology and Critical Care Medicine, Hartcentrum Hasselt, Jessa Ziekenhuis, Belgium; Faculty of Medicine and Life Sciences, University of Hasselt, Hasselt, Belgium.
Shamir MehtaDepartment of Medicine, McMaster University, Hamilton, Ontario, Canada; Hamilton Health Sciences, Hamilton, Ontario, Canada.
Sung-Jin HongDepartment of Cardiology, CHA Bundang Medical Center, CHA University College of Medicine, Seongnam, South Korea.
Kenji AndoKokura Memorial Hospital, Department of Cardiology, Kitakyushu, Japan.
Hyeon-Cheol GwonHeart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Paolo CalabròDepartment of Translational Medical Sciences, University of Campania Luigi Vanvitelli, Caserta, Italy.
Patrick W SerruysDepartment of Cardiology, National University of Ireland Galway, Galway, Ireland; NHLI, Imperial College London, London, United Kingdom.
George D DangasIcahn School of Medicine at Mount Sinai, New York, New York, USA.
Eùgene P McFaddenCardialysis Core Laboratories and Clinical Trial Management, Rotterdam, the Netherlands; Department of Cardiology, Cork University Hospital, Cork, Ireland.
Dominick J AngiolilloDivision of Cardiology, University of Florida College of Medicine, Jacksonville, Florida, USA.
Dik HegClinical Trials Unit, Bern, Switzerland.
Marco ValgimigliDepartment of Cardiology, Bern University Hospital, University of Bern, Bern, Switzerland; Cardiocentro Ticino Institute, Ente Ospedaliero Cantonale, Lugano, Switzerland. Electronic address: marco.valgimigli@eoc.ch.
Single Versus Dual Antiplatelet Therapy (Sidney-2) Collaboration
CHA University Bundang Medical Center · KRSamsung Medical Center · KRIcahn School of Medicine at Mount Sinai · USKyoto University · JPShanghai Jiao Tong University · CNUniversity of Campania "Luigi Vanvitelli" · ITBeth Israel Deaconess Medical Center · USCork University Hospital · IEEnte Ospedaliero Cantonale · CHHamilton Health Sciences · CAJessa Hospital · BEKokura Memorial Hospital · JPOllscoil na Gaillimhe – University of Galway · IEUniversity of Bern · CHUniversity of Florida · USUniversity of Naples Federico II · ITUniversity of Oklahoma Health Sciences Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIt remains unclear whether P2Y

objectivesWe sought to assess the effects of P2Y

methodsWe pooled patient-level data from randomized controlled trials comparing P2Y

resultsOf 22,941 patients undergoing PCI from 5 trials, 4,685 (20.4%) with complex PCI had higher rates of ischemic events. The primary efficacy endpoint was similar between P2Y

conclusionsP2Y

Indexed as

Percutaneous Coronary InterventionPlatelet Aggregation InhibitorsAspirinDrug Therapy, CombinationDual Anti-Platelet TherapyHemorrhageHumansPurinergic P2Y Receptor AntagonistsTreatment OutcomeAspirinPlatelet Aggregation InhibitorsPurinergic P2Y Receptor Antagonistscomplex PCIDAPTmeta-analysisP2Y(12) inhibitorspercutaneous coronary intervention

Identifiers

PMID36754514
OpenAlexW4319302851

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.