Evidence map›Paper›PMID 36754285›Full record

ReviewAdvanced drug delivery reviews2023

Nanobodies: Robust miniprotein binders in biomedicine.

Jeffrey Yong Joon Kim, Zhe Sang, Yufei Xiang, Zhuolun Shen, Yi Shi

Open access · greenAbstract readReview
In one paragraph

Review in Advanced drug delivery reviews, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
15.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 69 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Monoclonal Antibodies Targeting Bacterial Infections: A Broad Review of the Field.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Jeffrey Yong Joon KimCenter of Protein Engineering and Therapeutics, Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, 1, Gustave L. Levy Pl, New York, NY 10029, USA; Medical Scientist Training Program, University of Pittsburgh School of Medicine and Carnegie Mellon University, Pittsburgh, PA, USA.
Zhe SangCenter of Protein Engineering and Therapeutics, Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, 1, Gustave L. Levy Pl, New York, NY 10029, USA.
Yufei XiangCenter of Protein Engineering and Therapeutics, Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, 1, Gustave L. Levy Pl, New York, NY 10029, USA.
Zhuolun ShenState Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.
Yi ShiCenter of Protein Engineering and Therapeutics, Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, 1, Gustave L. Levy Pl, New York, NY 10029, USA. Electronic address: yi.shi@mssm.edu.
Icahn School of Medicine at Mount Sinai · USSun Yat-sen University · CNUniversity of Pittsburgh · US

Funding

Development of multivalent, ultrapotent nanobody cocktails for SARS-CoV-2 neutralizationR01AI163011 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI William Paul Duprex, Yi Shi · 2022 to 2026
$3.1M
Mapping the Dynamic Interactome of Ig-fold Membrane Proteins Using Nanobody-Based ToolsR35GM137905 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Yi Shi · 2020 to 2026
$2.8M
Using nanobodies to increase the sensitivity and resolution of chromatin profiling through uliCUT&RUNR21CA261737 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HAINER, SARAH JANE, SHI, YI · 2021 to 2023
$594k
NCI NIH HHS R21 CA261737NIAID NIH HHS R01 AI163011NIGMS NIH HHS R35 GM137905
6 · The paper itself

Abstract

Variable domains of heavy chain-only antibodies (V

Indexed as

Escherichia coliSingle-Domain AntibodiesProtein EngineeringUnited StatesSingle-Domain AntibodiesMultivalent nanobodiesProtein engineeringSARS-CoV-2V(H)H

Identifiers

PMID36754285
PMCPMC11725230
OpenAlexW4319442922

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.