Evidence map›Paper›PMID 36754138›Full record

SynthesisBrain research2023

Pain-related opioidergic and dopaminergic neurotransmission: Dual meta-Analyses of PET radioligand studies.

Sergio Garcia Guerra, Andrea Spadoni, Jennifer Mitchell, Irina A Strigo

Open access · greenAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Brain research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Sergio Garcia GuerraResearch Service, San Francisco Veterans Affairs Health Care Center, 4150 Clement Street, San Francisco, CA 94121, USA; University of California San Francisco, 505 Parnassus Ave, San Francisco, CA 94143, USA.
Andrea SpadoniResearch Service, San Diego Veterans Affairs Health Care Center, USA; University of California San Diego, La Jolla, CA 92093, USA.
Jennifer MitchellResearch Service, San Francisco Veterans Affairs Health Care Center, 4150 Clement Street, San Francisco, CA 94121, USA; University of California San Francisco, 505 Parnassus Ave, San Francisco, CA 94143, USA.
Irina A StrigoResearch Service, San Francisco Veterans Affairs Health Care Center, 4150 Clement Street, San Francisco, CA 94121, USA; University of California San Francisco, 505 Parnassus Ave, San Francisco, CA 94143, USA. Electronic address: Irina.Strigo@ucsf.edu.
San Francisco VA Medical Center · USVeterans Health Administration · US

Funding

UCSF Core Center for Patient-centric Mechanistic Phenotyping in Chronic Low Back PainU19AR076737 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LOTZ, JEFFREY C. · 2019 to 2023
$34.1M
CSRD VA I01 CX001652CSRD VA I01 CX001762CSRD VA I01 CX002397NIAMS NIH HHS U19 AR076737
6 · The paper itself

Abstract

Molecular mechanisms of the interaction between opioidergic and dopaminergic processing during pain-related experiences in the human brain are still incompletely understood. This is partially due to the invasive nature of the available techniques to visualize and measure metabolic activity. Positron Emission Tomography (PET) radioligand studies using radioactive substances are still the only available modality to date that allows for the investigation of the molecular mechanisms in the human brain. The most commonly studied PET radiotracers are [

Indexed as

Analgesics, OpioidDopamineBrainHumansPainPositron-Emission TomographyAnalgesics, OpioidDopamineDopamine receptorOpioid receptorPain modulationPET RadioligandsReward systemStriatum

Identifiers

PMID36754138
PMCPMC11018310
OpenAlexW4319320707

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.