Evidence map›Paper›PMID 36754129›Full record

ArticleJournal of biomedical informatics2023

Extracting medication changes in clinical narratives using pre-trained language models.

Giridhar Kaushik Ramachandran, Kevin Lybarger, Yaya Liu, Diwakar Mahajan, Jennifer J Liang, Ching-Huei Tsou, Meliha Yetisgen, Özlem Uzuner

Abstract read
In one paragraph

Article in Journal of biomedical informatics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. AI-Based Automation for Medication Reconciliation: Scoping Review.Journal of medical Internet research · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Clinical natural language processing for secondary uses.Journal of biomedical informatics · 2024
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Giridhar Kaushik RamachandranDepartment of Information Sciences & Technology, George Mason University, Fairfax, VA, United States of America. Electronic address: gramacha@gmu.edu.
Kevin LybargerDepartment of Information Sciences & Technology, George Mason University, Fairfax, VA, United States of America.
Yaya LiuDepartment of Information Sciences & Technology, George Mason University, Fairfax, VA, United States of America.
Diwakar MahajanIBM T.J. Watson Research Center, Yorktown Heights, NY, United States of America.
Jennifer J LiangIBM T.J. Watson Research Center, Yorktown Heights, NY, United States of America.
Ching-Huei TsouIBM T.J. Watson Research Center, Yorktown Heights, NY, United States of America.
Meliha YetisgenDepartment of Biomedical Informatics and Medical Education, University of Washington, Seattle, WA, United States of America.
Özlem UzunerDepartment of Information Sciences & Technology, George Mason University, Fairfax, VA, United States of America.

Funding

University of Washington Biomedical Informatics and Data Science Research Training ProgramT15LM007442 · NLM · UNIVERSITY OF WASHINGTON · PI JOHN H. GENNARI, Andrea L. Hartzler · 2002 to 2026
$19.6M
Large scale clinical and economic impact analysis of potentially malignant incidental findings in radiology reportsR01CA248422 · NCI · UNIVERSITY OF WASHINGTON · PI GUNN, MARTIN, YETISGEN, MELIHA · 2021 to 2024
$2.6M
Leveraging Unlabeled and Pseudo Data for Clinical Information ExtractionR15LM013209 · NLM · GEORGE MASON UNIVERSITY · PI UZUNER, OZLEM · 2019 to 2022
$840k
NCI NIH HHS R01 CA248422NLM NIH HHS R15 LM013209NLM NIH HHS T15 LM007442
6 · The paper itself

Abstract

An accurate and detailed account of patient medications, including medication changes within the patient timeline, is essential for healthcare providers to provide appropriate patient care. Healthcare providers or the patients themselves may initiate changes to patient medication. Medication changes take many forms, including prescribed medication and associated dosage modification. These changes provide information about the overall health of the patient and the rationale that led to the current care. Future care can then build on the resulting state of the patient. This work explores the automatic extraction of medication change information from free-text clinical notes. The Contextual Medication Event Dataset (CMED) is a corpus of clinical notes with annotations that characterize medication changes through multiple change-related attributes, including the type of change (start, stop, increase, etc.), initiator of the change, temporality, change likelihood, and negation. Using CMED, we identify medication mentions in clinical text and propose three novel high-performing BERT-based systems that resolve the annotated medication change characteristics. We demonstrate that our proposed systems improve medication change classification performance over the initial work exploring CMED.

Indexed as

LanguageNatural Language ProcessingHumansNarrationInformation extractionMachine learningMedication informationNatural language processing

Identifiers

PMID36754129
PMCPMC10291712

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.